Cancer Whole Exome Sequencing with Transcriptome
| Purpose: | Detects actionable constitutional changes predisposing to cancer; detects cancer specific missense, indel and copy number changes as well as chimeric RNAs and RNAs with altered expression levels using combination of exome and transcriptome sequencing |
| CPT Codes: | 81415, 81416, 81479 |
| Methodology: | Next Generation Sequencing of mRNA and DNA |
| Turnaround Time: | 60 days |
| Specimen: | Frozen tissue. A normal control sample (e.q. blood or buccal swab) is required for this testing. |
| Associated documents: | Cancer Genes (Cosmic): COSMIC genes reported on Coverage Disclaimer: WES regions not guaranteed greater than 10 fold COSMIC gene exons not guaranteed greater than 30 fold Recurrent COSMIC mutations not guaranteed to be covered greater than 30 fold |
| Secondary Findings: | ACMG Secondary Findings List |
| Forms: | 1. To inquire about ordering this test please contact: PGMINQUIRY@cumc.columbia.edu 2. Cancer Whole Exome Informed Consent 3. Insurance Pre-Authorization Form 4. Medicare Advance Beneficiary Notice Form 5. CWES Letter of Medical Necessity Template |