Batal Lab: recurrent and de novo diseases in the transplanted kidney
Location and Contact Information
- Email: ib2349@cumc.columbia.edu
Principal Investigator
Our research focuses on assessing the pathogenesis of glomerular diseases in the kidney allograft, including recurrent and de novo disease. Kidney transplantation offers unique environment to dissect culprit factors from recipients and donors that contribute to the histologic manifestations of glomerular diseases. We lead large studies involving several collaborators in differnt medical centers accross the globe.
Participating Centers
Lab Members
Lab Members
Maria D Belvis
- Technician
Amadea Toutoungis
- Student
Select Publications
Batal I, Mikhailov AV, Husain SA, Nuccitelli RA, Zanoni F, Liu L, Lim TY, Mohan S, DiFranza LT, Kudose S, Santoriello D, Sekulic M, Stokes MB, Markowitz GS, Ratner LE, D'Agati VD, Vasilescu ER, Gardner KL, Sanna-Cherchi S, Freedman BI, Kiryluk K, Mena Gutierrez AM. Association of Collapsing Glomerulopathy with Donor APOL1 Risk Variants in Kidney Allografts from Black Donors. Clin J Am Soc Nephrol. 2025 Jul 7;20(9):1268-1276.
Sethi S, Madden B, Moura MC, Nasr SH, Alexander MP, Debiec H, Torrel N, Gross L, Negron V, Specks U, Fervenza FC, Haas M, Ronco P, Batal I. FAT1 is a target antigen in a subset of de novo allograft membranous nephropathy associated with antibody mediated rejection. Kidney Int. 2024 Nov;106(5):985-990.
Batal I, Watts AJ, Gibier JB, Hamroun A, Top I, Provot F, Keller K, Ye X, Fernandez HE, Leal R, Andeen NK, Crew RJ, Dube GK, Vasilescu ER, Ratner LE, Bowman N, Bomback A, Sanna-Cherchi S, Kiryluk K, Weins A. Pre-transplant Anti-Nephrin Antibodies are Specific Predictors of Recurrent Diffuse Podocytopathy in the Kidney Allograft. Kidney Int. 2024 Oct;106(4):749-752.
Tarragón B, Peleg Y, Jagannathan G, Sekulic M, Chang JH, Cohen DJ, Crew RJ, Dube GK, Fernandez HE, Husain SA, Mohan S, Morris HK, Appel G, Jadav P, Santoriello D, Kudose S, Stokes MB, Batal I, Bomback A. C3 Glomerulopathy Recurs Early after Kidney Transplantation in Serial Biopsies Performed within the First Two Years Post-Transplantation Clin J Am Soc Nephrol. 2024 Aug 1;19(8):1005-1015.
Kavanagh C, Zanoni F, Leal R, Jain NG, Stack M, Vasilescu ER, Serban G, Shaut C, Kamal J, Kudose S, Martinho A, Alves R, Santoriello D, Canetta PA, Cohen D, Radhakrishnan J, Appel GB, Stokes MB, Markowitz GS, D’Agati VD, Kiryluk K, Andeen NK, Batal I. Clinical Predictors and Prognosis of Recurrent IgA Nephropathy in the Kidney Allograft. Glomerular Dis. 2022;2:42–53.
Batal I, Vasilescu ER, Dadhania DM, Adel AA, Husain SA, Avasare R, Serban G, Santoriello D, Khairallah P, Patel A, Moritz MJ, Latulippe E, Riopel J, Khallout K, Swanson SJ, Bomback AS, Mohan S, Ratner L, Radhakrishnan J, Cohen DJ, Appel GB, Stokes MB, Markowitz GS, Seshan SV, De Serres SA, Andeen N, Loupy A, Kiryluk K, D'Agati VD. Association of HLA Typing and Alloimmunity With Posttransplantation Membranous Nephropathy: A Multicenter Case Series. Am J Kidney Dis. 2020 Sep;76(3):374-383.
Santoriello D, Husain SA, De Serres SA, Bomback AS, Crew RJ, Vasilescu ER, Serban G, Campenot ES, Kiryluk K, Mohan S, Hawkins GA, Hicks PJ, Cohen DJ, Radhakrishnan J, Stokes MB, Markowitz GS, Freedman BI, D’Agati VD, Batal I. Donor APOL1 high-risk genotypes are associated with increased risk and inferior prognosis of de novo collapsing glomerulopathy in renal allografts. Kidney Int. 2018 Dec;94(6):1189-1198.
Batal I, Burke P, Kudose S, Crew RJ, Alexander MP, Sethi S. Temporal proteomic assessment of glomerular FAT1 in de novo membranous nephropathy of the kidney allograft. Kidney Int Rep. 2025 Aug 5;10(10):3681-3684.