Yvette C. Tanhehco, MD, PhD, MS

Blood Banking/Transfusion Medicine
Pathology - Clinical
More specialties
Accepting New Patients
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The aim of medicine is to prevent disease and prolong life; the ideal of medicine is to eliminate the need of a physician.
--William J. Mayo

Dr. Tanhehco is Associate Professor of Pathology and Cell Biology at Columbia University Irving Medical Center/NewYork-Presbyterian Hospital.  She has been a faculty member and attending physician in the Division of Transfusion Medicine and Cellular Therapy since 2012. She is the Director of the Cellular Therapy Laboratory and Assistant Director of Transfusion Medicine at NewYork-Presbyterian Hospital.

Dr. Tanhehco received her BA degree in Biological Sciences with concentrations in Microbiology and Molecular and Cell Biology from Cornell University in 1999. She then pursued graduate studies at Johns Hopkins University School of Medicine where she earned her PhD degree in Viral Oncology in 2004. Her interest in clinical care and medicine led her to the University of Pittsburgh where she obtained her MD degree in 2008.  She subsequently pursued residency training in Clinical Pathology (2008-2011) and fellowship training in Blood Banking/Transfusion Medicine (2011-2012) at the Hospital of the University of Pennsylvania. While at the University of Pennsylvania, she also obtained a MS degree in Translational Research (2010-2012). She is board certified by the American Board of Pathology in both Clinical Pathology and Blood Banking/Transfusion Medicine.

Dr. Tanhehco’s clinical and research interests focus on cellular and gene therapies for malignant and non-malignant disease particularly sickle cell disease.  She is interested in strategies to optimize patients and procedures for apheresis collections of mononuclear cells and hematopoietic progenitor cells to minimize patient adverse events and improve cell yields for drug product manufacturing.  She is also interested in methods to improve processing and cryopreservation of mononuclear cell and peripheral blood stem cell products.

Dr. Tanhehco is an active member of several professional societies including the Association for the Advancement of Blood and Biotherapies, American Society for Apheresis, International Society for Cell and Gene Therapy, College of American Pathologists, and American Society for Clinical Pathology. She has authored over 50 peer-reviewed publications.

Email: yct2103@cumc.columbia.edu

Areas of Expertise / Conditions Treated

  • Apheresis
  • Blood Bank
  • Cellular Therapy
  • Clinical Pathology
  • Transfusion Medicine

Academic Appointments

  • Associate Professor of Pathology and Cell Biology at CUMC

Administrative Titles

  • Assistant Director, Transfusion Medicine; Director, Cellular Therapy Laboratory

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Taiwanese


  • Female

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Credentials & Experience

Education & Training

  • University of Pittsburgh School Of Medicine
  • Johns Hopkins University
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: 2012 Hospital Of The University Of Pennsylvania

Committees, Societies, Councils

2008- Present College of American Pathologists

2009- Present American Association of Blood Banks

2010- Present American Society for Apheresis

2015- Present Blood Bank Association of New York

Board Certifications

  • Clinical Pathology
  • Blood Banking/Transfusion Medicine

Honors & Awards

1998 Golden Key International Honour Society

1999 Distinction in All Subjects, Cornell University

2004 Honorable mention, National Science Foundation Graduate Research Fellowship

2005 Summer Research Fellowship, National Science Foundation East Asia and Pacific Summer Institutes

2016 Leading Physicians of the World

2016 Leading Physicians of the World


Selected Publications

  • Tanhehco YC, Schwartz J, Linenberger ML. Defining the Quality of Hematopoietic Stem Cell Products - The Devil is in the Details. Transfusion 2015; 55(10): 2300-2303.
  • Paroder-Belenitsky M and Tanhehco YC. Extracorporeal photopheresis drive tube leak due to end‐user misload. Transfusion 2015; 55(8):1829.
  • Metjian A, Tanhehco YC, Aqui N, Bhoj V, Jamensky L, Marques M, Onwuemene O, Pham HP, Arepally G. The Thrombotic Microangiopathy Registry of North America (TRNA): A United States Multi-Institutional TMA Network. J Clin Apher 2016; 31(5):448-53.
  • Tanhehco YC, Weisberg S, Schwartz J. Pancreatic Islet Autotransplantation for Nonmalignant and Malignant Indications. Transfusion 2016; 56(3):761-770.
  • McMahon CM, Tanhehco YC, and Cuker A. Inappropriate documentation of heparin as an allergy in the medical record due to misdiagnosis of heparin-induced thrombocytopenia: frequency and consequences. J Thromb Haemost 2017; 15(2):370-374.
  • Tanhehco YC, Arepally G, Metjian, A. Novel therapeutic approaches for thrombotic thrombocytopenic purpura. Curr Opin Hematol 2017;24(6):521-528.
  • Tanhehco YC, Bhatia M. Hematopoietic stem cell transplantation and cellular therapy in sickle cell disease: where are we now? Curr Opin Hematol 2019; 26(6):448-452.
  • Thibodeaux SR, Tanhehco YC, Irwin L, Jamensky L, Schell K, O’Doherty U. More efficient exchange of sickle cell red blood cells can be achieved by exchanging the densest red blood cells: An ex vivo proof of concept study. Transfus Apher Sci 2019 Feb;58(1):100-106.
  • Tanhehco YC, Zantek ND, Alsammak M, Chhibber V, Li Y, Becker J, Wu DW, Foster T, Wehrli G. Vascular access practices for therapeutic apheresis: Results of a survey. J Clin Apher 2019 Oct;34(5):571-578.
  • Karafin MS, Hendrickson JE, Kim HC, Kuliya-Gwarzo A, Pagano MB, Perumbeti A, Shi PA, Tanhehco YC, Webb J, Wong E, Eichbaum Q. Red cell exchange for patients with sickle cell disease: an international survey of current practices. Transfusion 2020 Jun 24. Doi:10.1111/trf.15863. Online ahead of print.
  • Tanhehco YC and Schwartz J. How the COVID-19 Pandemic Changed Cellular Therapy at Columbia University Irving Medical Center/NewYork-Presbyterian Hospital. Transfusion 2020 Jun 24. Doi:10.1111/trf.15956. Online ahead of print.