Hee Won Yang, PhD

  • Assistant Professor of Pathology & Cell Biology
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Email: hy2602@cumc.columbia.edu

Laboratory website: Yang Lab

Academic Appointments

  • Assistant Professor of Pathology & Cell Biology


  • Korean


Our lab focuses on understanding the signaling processes that underlie the decision to proliferate. Although many proteins regulating proliferation have been identified, it is still unclear how these central components are wired into circuits to carry out the decision of proliferation. In particular analysis of signaling dynamics in space and time and tools to probe interactions between components have been missing. To address these questions, we apply an automated imaging system and live-cell biosensors to monitor signaling processes at the single-cell level. We classify heterogeneous population and further explore underlying molecular mechanism. We are currently studying the decision of proliferation in normal condition and pathological condition, cancer.

Research Interests

  • Cancer Biology
  • Cell biology
  • Synthetic Biology
  • Systems Biology

Selected Publications

*Co-first authors, #Co-corresponding authors

  • C Liu, Y Konagaya, M Chung, LH Daigh, Y Fan, H Yang, K Terai, M Matsuda, T Meyer, Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity. Nat Comm, 11: 5305, 2020
  • H Yang*#, SD Cappell*, A Jaimovich*, C Liu, M Chung, S Regot, M Covert, and Tobias Meyer#, Stress-mediated exit to quiescence restricted by progressively increasing persistence in CDK4/6 activation. eLife, 9, 2020
  • M Chung, C Liu, H Yang, MS Koberlin, SD Cappell, and T Meyer. Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1. Mol Cell, 76(4): 562-573, 2019
  • TYC Tsai, SR Collins, CK Chan, P Lam, SS Lou, H Yang, MW Davidson, RS Fischer, A Huttenlocher, T Meyer, JE Ferrell, and JA Theriot. Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell, 49(2): 189-205, 2019
  • HW Yang#, M Chung, T Kudo, and T Meyer#. Competing memories of mitogen and p53 signaling control cell-cycle entry. Nature, 549: 404-408, 2017 (cover article)
  • HW Yang*#, SR Collins*#, and T Meyer#. Locally excitable Cdc42 signals steer cells during chemotaxis. Nat Cell Biol, 18: 191-201, 2016
  • SR Collins, HW Yang, KM Bonger, EG Guignet, TJ Wandless, and T Meyer. Using light to shape chemical gradients for parallel and automated analysis of chemotaxis. Mol Sys Biol, 11(4): 804, 2015
  • HW Yang, MK Shin, S Lee, J Kim, WS Park, K Cho, T Meyer, and WD Heo. Cooperative activation of PI3K by Ras and Rho family small GTPases. Mol Cell, 47: 281-290, 2012
  • J Won*, HW Yang*, SY Shin*, JH Lee, WD Heo, and K Cho. The cross regulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor. J Mol Cell Biol, 4: 153-163, 2012 (Cover article)
  • SY Shin*, HW Yang*, J Kim, WD Heo, and K Cho. A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network. J Cell Science, 124: 82-90, 2011 (cover article)