Dr. Steven Spitalnik, MD is the Co-Director of the Laboratory of Transfusion Biology, which pursues NIH-funded research aimed at improving transfusion practice. Dr. Spitalnik is a Professor of Pathology and Cell Biology and the Vice-Chairman of Laboratory Medicine at Columbia University Medical Center (CUMC). As the Medical Director of the Clinical laboratories on the CUMC campus of the New York-Presbyterian Hospital, he coordinates the clinical service, educational, and scholarly activities of the Division. He is a long-standing member of the Academy of Clinical Laboratory Physicians & Scientists, serving as its President in 2002-03 and, in 2005, receiving its Gerald T. Evans Award for outstanding leadership and service to the Academy. In addition to being board certified in both Anatomic and Clinical Pathology, Dr. Spitalnik is a member of the Editorial Boards of Transfusion, Transfusion Medicine Reviews, and Current Opinion in Hematology, and is the lead author of Clinical Pathology Board Review.
Areas of Expertise / Conditions Treated
- Blood Bank
- Sickle Cell Anemia
- Transfusion Medicine
- Professor of Pathology & Cell Biology
- Executive Vice Chair; Vice Chair for Laboratory Medicine
- NewYork-Presbyterian / Columbia University Irving Medical Center
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- Aetna Signature Administrators
- Medicare Managed Care
- NYP Employee Plan
- NY Signature
- Student Health
- Great West (National)
- Medicare Managed Care
- Essential Plan
- Medicaid Managed Care
- Medicare Managed Care
- Select Care (Exchange)
Empire Blue Cross/Blue Shield
- Local 1199
- Traditional Medicare
Oxford Health Plans
- Special Needs
- Columbia University Employee Plan
- Compass (Exchange)
- Empire Plan
- Medicare Managed Care
Credentials & Experience
Education & Training
- University of Chicago Pitzker School of Medicine
- Internship: University of Rochester
- Residency: University of Rochester
- Fellowship: University of Rochester
- Fellowship: 1985 National Institutes of Health
Honors & Awards
1974 Phi Beta Kappa
1974 Honors in Mathematics, Princeton University
1981, 1982, 1983 Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists
1987-1990 Junior Faculty Research Award, American Cancer Society
1987-1992 FIRST Award, National Institutes of Health
1989-1992 Mallinckrodt Scholar
1989 Class of `92 Commendation for Outstanding Teaching, University of Pennsylvania
1990 Class of `93 Commendation for Outstanding Teaching, University of Pennsylvania
1991 Dean's Award for Excellence in Basic Science Teaching, University of Pennsylvania
1991 US-Poland Individual Health Scientist Exchange Program Fellowship, Fogarty International Center
1992 Class of `95 Commendation for Outstanding Teaching, University of Pennsylvania
1994 Elected to American Society for Clinical Investigation
1995 Peter C. Nowell Teaching Award, University of Pennsylvania
1995 FASEB Visiting Scientist; Barry University, Miami Shores, FL. The role of glycosylation of ÃŸ-amyloid precursor protein in the pathogenesis of Alzheimer's disease.
1996 Penn Pearls Teaching Award, University of Pennsylvania
1996 Leonard Berwick Memorial Teaching Award, University of Pennsylvania
1996 Class of `99 Commendation for Outstanding Teaching, University of Pennsylvania
1997 Class of `00 Commendation for Outstanding Teaching, University of Pennsylvania
1997 Annual Meeting of the American Association of Blood Banks, Denver, CO. Workshop organizer and speaker: A Transfusion Medicine Primer
1998 Christian R. and Mary F. Lindback Foundation Teaching Award, University of Pennsylvania
1999 Sherwood Smith Memorial Lectureship, New York Association of Blood Banks Annual Meeting, Rochester, NY. The impact of molecular biology on the practice of transfusion medicine.
2002 Faculty Mentor Award, 4th Annual Marvin J. Hoffman Day, University of Rochester
2002 Short course on the biochemistry of the red blood cell membrane, Annual Meeting of the American Association of Blood Banks, Orlando, FL. Glycobiology of the red blood cell membrane
2002 Short course on human carbohydrate blood group antigens, Annual Meeting of the American Association of Blood Banks, Orlando, FL. The Lewis blood group system
2003 Eric A. Schenk Award for Excellence in Teaching, University of Rochester
2005 Gerald T. Evans Award for outstanding leadership and service to the academy, Academy of Clinical Laboratory Physicians & Scientists
2013 Graham A. Jamieson Memorial Lectureship, American Red Cross
2013 Emily Cooley Award and Lectureship, American Association of Blood Banks
2016 Elected to Hall of Fame, National Blood Foundation
2016 Inaugural Class, Academy of Clinical Mentoring and Excellence, Columbia University College of Physicians & Surgeons
My research program in the Laboratory of Transfusion Biology uses in vitro systems, mouse models, and human studies to investigate important problems related to red blood cell biology. We are particularly interested in improving the quality of red blood cell transfusions, and preventing or ameliorating the adverse effects resulting from this therapeutic intervention. As a result, we study the consequences of refrigerated storage, alloimmunization, and hemolytic transfusion reactions. We have a particular interest in the role of oxidative stress during refrigerated storage of red blood cells and its effects on red blood cell storage quality. In addition, we study the role of iron deficiency, iron supplementation, and iron metabolism in the biology of malaria, bacterial infections, and co-infections of malaria with bacterial pathogens. Results from these studies provided the impetus for the “iron hypothesis” to explain some of the adverse effects of red blood cell transfusion, particularly with regard to infectious disease.
- The biology of red blood cells
Zimring JC, Smith N, Stowell SR, Johnsen JM, Bell LN, Francis RO, Hod EA, Hendrickson JE, Roback JD, Spitalnik SL. Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion 54:137-148, 2014.
LaRocca TJ, Stivison EA, Hod EA, Spitalnik SL, Cowan PJ, Randis TM, Ratner AJ. Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. mBio 5(5):e01251-14, 2014.
Prestia K, Bandyopadhyay S, Slate A, Francis RO, Francis KP, Spitalnik SL, Fidock DA, Brittenham GM, Hod EA. Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice. Transfusion 54:2842-2851, 2014.
Wojczyk BS, Kim N, Bandyopadhyay S, Francis RO, Zimring JC, Hod EA, Spitalnik SL. Macrophages clear refrigerator storage-damaged RBCs and subsequently secrete cytokines in vivo, but not in vitro, in a murine model. Transfusion 54:3186-3197, 2014.
LaRocca T, Stivison E, Mal-Sarkar T, Hooven T, Hod E, Spitalnik SL, Ratner A. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Cell Death and Disease 6:e1773; doi:10.1038/cddis.2015.135, 2015
Xu JZ, Francis RO, Lerebours Nadal LE, Shirazi M, Jobanputra V, Hod EA, Jhang JS, Stotler BA, Spitalnik SL, Nicholas SW. G6PD Deficiency in an HIV Clinic Setting in the Dominican Republic. American Journal of Tropical Medicine and Hygiene 93:722-729, 2015.
Waterman HR, Kapp LM, Howie HL, Hod EA, Spitalnik SL, Zimring JC. Analysis of 24-h recovery of transfused stored RBCs in recipient mice of distinct genetic backgrounds. Vox Sanguinis 109:148-154, 2015.
L'Acqua C, Bandyopadhyay S, Francis RO, McMahon DJ, Nellis M, Sheth S, Kernie SG, Brittenham GM, Spitalnik SL, Hod EA. Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children. American Journal of Hematology 90:915-920, 2015.
Zimring JC, Spitalnik SL. Pathobiology of haemolytic transfusion reactions. Annual Review of Pathology 10:83-110, 2015.
Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NLC, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S for the State of the Science in Transfusion Medicine Working Groups. 2015 Proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine Symposium. Transfusion55:2282-2290, 2015.
Calabro S, Gallman A, Gowthaman U, Liu D, Chen P, Liu J, Krishnaswamy JK, Nascimento MSL, Xu L, Patel SR, Williams A, Tormey CA, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE, Stowell SR, Eisenbarth SC. Bridging channel dendritic cells induce immunity to transfused red blood cells.Journal of Experimental Medicine 213:887-896, 2016.
Youssef LA, Spitalnik SL. Transfusion-related immunomodulation: a reappraisal. Curr Opin Hematol. 2017 Nov;24(6):551-557. doi: 10.1097/MOH.0000000000000376.PMID: 28806274
Youssef LA, Rebbaa A, Pampou S, Weisberg SP, Stockwell BR, Hod EA, Spitalnik SL. Increased Erythrophagocytosis Induces Ferroptosis in Red Pulp Macrophages in a Mouse Model of Transfusion. Blood. 2018 Jun 7;131(23):2581-2593. doi: 10.1182/blood-2017-12-822619. Epub 2018 Apr 17.PMID: 29666112
Thomas T, Spitalnik SL. Hitchhiker's Guide to the Red Blood Cell Storage Lesion. Blood Transfus. 2019 Jan;17(1):1-3. doi: 10.2450/2019.0257-18.PMID: 30653457
Francis RO, D'Alessandro A, Eisenberger A, Soffing M, Yeh R, Coronel E, Sheikh A, Rapido F, La Carpia F, Reisz JA, Gehrke S, Nemkov T, Thomas T, Schwartz J, Divgi C, Kessler D, Shaz BH, Ginzburg Y, Zimring JC, Spitalnik SL, Hod EA. Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. J Clin Invest. 2020 May 1;130(5):2270-2285. doi: 10.1172/JCI133530. PubMed PMID: 31961822.
Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, van Buskirk C, Grossman BJ, Joyner M, Henderson JP, Pekosz A, Lau B, Wesolowski A, Katz L, Shan H, Auwaerter PG, Thomas D, Sullivan DJ, Paneth N, Gehrie E, Spitalnik SL, Hod EA, Pollack L, Nicholson WT, Pirofski LA, Bailey JA, Tobian AA. Deployment of convalescent plasma for the prevention and treatment of COVID-19. J Clin Invest. 2020 Jun 1;130(6):2757-2765. doi: 10.1172/JCI138745.
Eckhardt CM, Cummings MJ, Rajagopalan KN, Borden S, Bitan ZC, Wolf A, Kantor A, Briese T, Meyer BJ, Jacobson SD, Scotto D, Mishra N, Philip NM, Stotler BA, Schwartz J, Shaz B, Spitalnik SL, Eisenberger A, Hod EA, Justman J, Cheung K, Lipkin WI, O'Donnell MR. Evaluating the efficacy and safety of human anti-SARS-CoV-2 convalescent plasma in severely ill adults with COVID-19: A structured summary of a study protocol for a randomized controlled trial. Version 2. Trials. 2020 Jun 8;21(1):499. doi: 10.1186/s13063-020-04422-y. PMID: 32513308
Thomas T, Stefanoni D, Reisz JA, Nemkov T, Bertolone L, Francis RO, Hudson KE, Zimring JC, Hansen KC, Hod EA, Spitalnik SL, D'Alessandro A. COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status. medRxiv. 2020 May 16:2020.05.14.20102491. doi: 10.1101/2020.05.14.20102491. Preprint. PMID: 32511571