Stephen M. Lagana, MD

Pathology - Anatomic
Accepting New Patients
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I am a surgical pathologist with sub-specialty expertise in GI and liver pathology. I am also the Quality Assurance Director for Anatomic Pathology. I graduated from University of Pittsburgh School of Medicine and performed my residency and fellowship at Columbia University.


Areas of Expertise / Conditions Treated

  • Celiac Disease
  • Gastrointestinal Pathology
  • Hepatocellular Carcinoma
  • Inflammatory Bowel Disease (IBD)
  • Liver Biopsy
  • Liver Pathology
  • Liver Tumors
  • Surgical Pathology

Academic Appointments

  • Associate Professor of Pathology & Cell Biology at CUMC

Administrative Titles

  • Co-Director, Quality Assurance for Anatomic Pathology; Associate Director, Surgical Pathology

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Male

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Insurance Accepted


  • Medicare Managed Care
  • Special Needs


  • EPO
  • Great West (National)
  • HMO
  • POS
  • PPO


  • Medicare Managed Care
  • PPO


  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross/Blue Shield

  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare (National)

  • MagnaCare


  • Railroad
  • Traditional Medicare


  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care


  • Special Needs


  • Columbia University Employee Plan
  • Compass (Exchange)
  • Empire Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center

Committees, Societies, Councils



Roger Haggitt GI Pathology Society

NY Path Society

Board Certifications

  • Anatomic Pathology


Research Interests

  • I am interested in non-neoplastic small bowel disease (e.g. celiac disease) and liver neoplasia.

Selected Publications

  • Lee M, Kudose S, …. Lagana SM. Invasive Carcinoma versus Pseudoinvasion: Interobserver Variability in the Assessment of Left-sided Colorectal Polypectomies. Accepted, pending publication; Journal of Clinical Pathology. 2021
  • Melms J, Biermann J, …..Lagana SM……Izar, B. A molecular single-cell lung atlas of lethal COVID-19. Accepted, pending publication, Nature. 2021.
  • Alpert L, Setia N, Ko HM, Lagana SM, Pittman ME, Johncilla M, Drage MG, Zhao L, Salomao MA, Liao X, Choi WT, Jenkins SM, Hart J, Harpaz N, Voltaggio L, Lauwers GY, Odze R, Remotti H, Smyrk TC, Graham RP. Interobserver agreement and the impact of mentorship on the diagnosis of inflammatory bowel disease-associated dysplasia among subspecialist gastrointestinal pathologists. Virchows Arch. 2021 Jan 3. doi: 10.1007/s00428-020-02998-z
  • Desai N…Lagana SM…Deshpande V. Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection. Nat Commun. 2020 Dec 9;11(1):6319. doi: 10.1038/s41467-020-20139-7.
  • Kmeid M, Zuo C, Lagana SM, Choi WT, Lin J, Yang Z, Liu X, Westerhoff M, Fiel MI, Affolter K, Choi EK, Lee H. Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension.  Diagn Pathol. 2020 Oct 23;15(1):129. doi: 10.1186/s13000-020-01049-0.
  • De Michele S, Remotti HE, Del Portillo A, Lagana SM, Szabolcs M, Saqi A. SATB2 in Neoplasms of Lung, Pancreatobiliary, and Gastrointestinal Origins. Am J Clin Pathol 2020 Sep 11;aqaa118
  • Van Treeck BJ, Mounajjed T, Moreira RK, Orujov M, Allende DS, Bellizzi AM, Lagana SM, Davila JI, Jessen E, Graham RP. Transcriptomic and Proteomic Analysis of Steatohepatitic Hepatocellular Carcinoma Reveals Novel Distinct Biologic Features. Am J Clin Pathol 2020 Sep 4;aqaa114. doi: 10.1093/ajcp/aqaa114
  • Lagana SM, Kudose S, Iuga AC, Lee MJ, Fazlollahi L, Remotti HE, Del Portillo A, De Michele S, de Gonzalez AK, Saqi A, Khairallah P, Chong AM, Park H, Uhlemann AC, Lefkowitch JH, Verna EC. Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data.  Mod Pathol  2020 Aug 13;1-9. doi: 10.1038/s41379-020-00649-x.
  • Lee M, Ko HM, Rubino A, Lee H, Gill R, Lagana SM. Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases. Diagn. Pathol. 2020, Jul 24; 15(1):97
  • Chen DA, Koehne de Gonzalez A, Fazlollahi L, Coffey A, Remotti HE, Lagana SM. In Situ Hybridisation for Albumin RNA in Paediatric Liver Cancers Compared With Common Immunohistochemical Markers.  J Clin Pathol. 2020 May 29;jclinpath-2020-206663.
  • Lagana SM, De Michele S, Lee MJ, Emond JC, Griesemer AD, Tulin-Silver SA, Verna EC, Martinez M, Lefkowitch JH. COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation. Arch Pathol Lab Med. 2020 Apr 17. doi: 10.5858/arpa.2020-0186-SA
  • Ross DS, Liu B, Schram AM, Razavi P, Lagana SM, Zhang Y, Scaltriti M, Bromberg JF, Ladanyi M, Hyman DM, Drilon A, Zehir A, Benayed R, Chandarlapaty S, Hechtman JF. Enrichment of Kinase Fusions in ESR1 Wild Type, Metastatic Breast Cancer Revealed by a Systematic Analysis of 4,854 Patients Ann Oncol. 2020 Apr 26:S0923-7534(20)39306-6. doi: 10.1016/j.annonc.2020.04.008.
  • Lee M, Betman S, Iuga A, Yang HM, Fleming J, Green PHR, Lebwohl B, Lagana SM. An association between crypt apoptotic bodies and mucosal flattening in celiac disease patients exposed to dietary gluten. Diagn Pathol. 2019 Aug 31;14(1):98. doi: 10.1186/s13000-019-0878-1
  • Yiping Han, Mara Roxana Rubinstein, Jungeun Baik, Stephen Lagana, Richard Han, William Raab, Debashish Sahoo, Piero Dalerba, and Timothy C. Wang. Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1.  EMBO Rep. 2019 Apr;20(4). pii: e47638. doi: 10.15252/embr.201847638. Epub 2019 Mar 4
  • Jung Hoon Son, Benjamin Lebwohl, Antonia Sepulveda, Stephen M. Lagana. Utilization Rate of Helicobacter pylori Immunohistochemistry is Not Associated with Diagnostic Rate of Helicobacter pylori Infection.  In Press. Applied Immunohistochemistry and Molecular Morphology (2018).
  • Shafinaz Hussein, Tatyana Gindin, Stephen M. Lagana, Carolina Arguelles-Grande, Suneeta Krishnareddy, Bachir Alobeid, Suzanne Lewis, Mahesh Mansukhani, Peter H. Green, Govind Bhagat. Clonal T-cell receptor gene rearrangements in celiac disease: implications for diagnosing refractory celiac disease.  Journal of Clinical Pathology.  Accepted, in-press (2018).
  • Ladan Fazlollahi, Helen E. Remotti, Alina Iuga, Hui-Min Yang, Stephen M. Lagana, and Antonia R. Sepulveda (2017) HER2 Heterogeneity in Gastroesophageal Cancer Detected by Testing Biopsy and Resection Specimens. Arch Pathol Lab Med. 2018 Apr;142(4):516-522.
  • Gonzalez RS, Lagana SM, Szeto O, Arnold CA. Challenges in Diagnosing Medication Resins in Surgical Pathology Specimens: A Crystal-Clear Review Guide. Arch Pathol Lab Med. 2017 Feb 7. doi: 10.5858/arpa.
  • Hemant Varma, Phyllis L. Faust, Alejandro D. Iglesias, Stephen M. Lagana, Karen Wou, Michio Hirano, Salvatore DiMauro, Mahesh M. Mansukani, Kirsten E. Hoff, Peter L. Nagy, William C. Copeland, Ali B. Naini. Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion. Eur J Med Gen. 2016
  • Sung D, Iuga AC, Kato T, Martinez M, Remotti HE, Lagana SM. Crypt Apoptotic Body Counts in Normal Ileal Biopsies Overlap with Graft Versus Host Disease and Acute Cellular Rejection of Small Bowel Allografts. Hum Pathol. 2016 May 28. pii: S0046-8177(16)30098-3. doi: 10.1016/j.humpath.2016.05.017. [Epub ahead of print] PMID: 27246175
  • Elizabeth Margolskee; Fei Bao; Anne Koehne de Gonzalez; Roger K Moreira; Stephen M Lagana; Anthony N Sireci; Antonia R Sepulveda; Helen E Remotti; Jay H Lefkowitch; Marcela Salomao, MD. Hepatocellular Adenoma Classification: A Comparative Evaluation of Immunohistochemistry and Targeted Mutational Analysis. Diagn Pathol. 2016 Mar 9;11(1):27. doi: 10.1186/s13000-016-0475-5.
  • Nina Burbure, Benjamin Lebwohl, Peter H.R. Green, Carolina Arguelles-Grande, Govind Bhagat, Stephen M. Lagana. Olmesartan Associated Sprue-like Enteropathy: a Systematic Review with Emphasis on Histopathology. Hum Pathol. 2016 Apr;50:127-34. doi: 10.1016/j.humpath.2015.12.001.
  • Taylor SA, Vittorio JM, Martinez M, Fester KA, Lagana SM, Lobritto SJ, Ovchinsky N. Anakinra-Induced Acute Liver Failure in an Adolescent Patient with Still's Disease. Pharmacotherapy. 2016 Jan 9. doi: 10.1002/phar.1677
  • Lefkowitch J, Lagana SM, Kato T. Hepatocellular Carcinoma in Noncirrhotic Liver with Glycogenotic Foci: Basic Science Meets Genomic Medicine. Semin Liver Dis. 2015 Nov;35(4):450-6. doi: 10.1055/s-0035-1568986
  • Stephen Lagana, Susan Hsiao, Fei Bao, Antonia Sepulveda, Roger Moreira, Jay Lefkowitch and Helen Remotti. HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region. Archives of Pathology & Laboratory Medicine Jun 2015, Vol. 139, No. 6 (June 2015) pp. 791-795
  • Armando, Del Portillo, Stephen M, Lagana, Yuan, Yao, Takeshi, Uehara, Nirag, Jhala, Tapan, Ganguly, Peter, Nagy, Jorge, Gutierrez, Aesis, Luna, Julian, Abrams, Yang, Liu, Randall, Brand, Jorge L, Sepulveda, Gary W, Falk, Antonia R, Sepulveda. Evaluation of Mutational Testing of Pre-neoplastic Barrett's Mucosa by Next Generation Sequencing of FFPE Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett's Esophagus. J Mol Diagn. 2015 Jul;17(4):412-9.
  • Anne K Koehne de Gonzalez, Marcela A Salomao and Stephen M Lagana. Current concepts in the immunohistochemical evaluation of liver tumors. World J Hepatol 7(10):1403-1411. Published online 2015 June 08. doi: 10.4254/wjh.v7.i10.1403
  • Lagana SM, Salomao M, Remotti HE, Knisely A.S., Moreira RK. Bile Salt Export Pump: a Sensitive and Specific Immunohistochemical Marker of Hepatocellular Carcinoma. Histopathology. 2015 Mar;66(4):598-602. doi: 10.1111/his.12601.
  • Melissa Latorre MD, Stephen M. Lagana MD, Daniel E. Freedberg MD, Benjamin Lebwohl MD, Govind Bhagat MD, Suzanne K. Lewis MD, Peter H.R. Green MD. Endoscopic biopsy technique in the diagnosis of celiac disease: one bite or two? Gastrointest Endosc. 2015 Jan 29. pii: S0016-5107(14)02380-3
  • Lagana SM, Braunstein ED, Arguelles-Grande C, Bhagat G, Green PH, Lebwohl B. Sprue-like histology in patients with abdominal pain taking olmesartan compared with other angiotensin receptor blockers. J Clin Pathol. 2015 Jan;68(1):29-32. doi: 10.1136/jclinpath-2014-202615.
  • Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR. An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard. Clin Imaging. 2014 Jun 4. pii: S0899-7071(14)
  • Hanna RF, Finkelstone LA, Chow DS, Miloushev VZ, Escudero MR, Lagana SM, Prince MR. Nephrogenic systemic fibrosis risk and liver disease. Int J Nephrol. 2014;2014:679605. doi: 10.1155/2014/679605. Epub 2014 Mar 23.PMID:24778878
  • Chen, X., Lagana, SM., Poneros, J., Kato, T., Remotti, F., He, H., Kaminsky, D. and Hamele-Bena, D. (2013), Cytological diagnosis of angiosarcoma arising in an immunosuppressed patient 6 years after multi-visceral transplantation. Diagn. Cytopathol.. doi: 10.1002/dc.23068
  • Lagana SM, Moreira, RK, Remotti HE, Bao F. Glutamine synthetase, Heat-shock Protein 70 and Glypican-3 in Intra-hepatic Cholangiocarcinoma and Tumors Metastatic to Liver. Appl Immunohistochem Mol Morphol. 2013 May;21(3):254-7. doi: 10.1097/PAI.0b013e3182642c9c.
  • Lagana SM, Salomao M, Bao F, Moreira RK, Lefkowitch, J, Remotti HE. Utility of an Immunohistochemical Panel Consisting of Glypican-3, Heat Shock Protein-70, and Glutamine Synthetase in the Distinction of Low-grade Hepatocellular Carcinoma from Hepatocellular Adenoma. Appl Immunohistochem Mol Morphol. 2013 Mar;21(2):170-6. doi: 10.1097/PAI.0b013e31825d527f.
  • Lagana SM, Taub RN, Borczuk AC. Utility of Glucose Transporter 1 in the Distinction of Benign and Malignant Thoracic and Abdominal Mesothelial Lesions. Arch Pathol Lab Med. 2012 Jul;136(7):804-9. doi: 10.5858/arpa.2011-0219-OA.
  • Guo-Xia Tong, Lorenzo Memeo, Cristina Colarossi, Diane Hamele-Bena, Cristina Magi-Galluzzi, Ming Zhou, Stephen M. Lagana, Lara Harik, Jennifer M. Oliver-Krasinski, Mahesh Mansukhani, Lorenzo Falcone, Hanina Hibshoosh, and Kathleen O'Toole. PAX8 and PAX2 Immunostaining Facilitates the Diagnosis of Primary Epithelial Neoplasms of the Male Genital Tract. Am J Surg Pathol. 2011 Oct;35(10):1473-83.
  • Lagana SM, Hanna RF, Borczuk AC. Pleomorphic (Spindle and Squamous Cell) Carcinoma Arising in a Peripheral Mixed Squamous and Glandular Papilloma in a 70 Year Old Man. Arch Pathol Lab Med. 2011 Oct;135(10):1353-6.
  • Lagana SM, Moreira RK, Lefkowitch JH. Hepatic Granulomas: Pathogenesis and Differential Diagnosis. Clin Liver Dis. 2010 Nov;14(4):605-17.PMID: 21055685
  • Lagana S, Parwani AV, Nichols L. Cardiac Sarcoidosis. A Pathology Focused Review. Arch Pathol Lab Med. 2010 Jul;134(7):1039-46.
  • Nichols L, Lagana S, Parwani A. Coronary Artery Aneurysm: a Review and Hypothesis Regarding Etiology. Arch Pathol Lab Med. 2008 May;132(5):823-8. Review.
  • London B, Michalec M, Mehdi H, Zhu X, Kerchner L, Sanyal S, Viswanathan PC, Pfahnl AE, Shang LL, Madhusudanan M, Baty CJ, Lagana S, Aleong R, Gutmann R, Ackerman MJ, McNamara DM, Weiss R, Dudley SC Jr. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias. Circulation. 2007 Nov 13;116(20):2260-8.