Shan Zha, MD, PhD

Profile Headshot

Overview

Academic Appointments

  • Associate Professor of Pathology and Cell Biology (in the Institute for Cancer Genetics and in the Herbert Irving Comprehensive Cancer Center)
  • Associate Professor of Pediatrics

Languages

  • Chinese

Gender

  • Female

Credentials & Experience

Education & Training

  • MD, 1998 Medicine, Peking University (China)
  • Fellowship: Children's Hospital Boston

Honors & Awards

2013-2018 Leukemia and Lymphoma Society Scholar
2013-2016 American Cancer Society Research Scholar Award
2012-2015 Gabrielle's Angel Foundation Medical Research Award
2010-2013 St. Baldrick Scholar for Pediatric Oncology
2010-2011 John M. Driscoll, Jr., M.D. Children's Fund Awards
2009 Bristol-Myers Squibb Oncology Award, American Association for Cancer Research
2007-2010 Senior Fellowship Award, Leukemia and Lymphoma Society
2004-2007 Fellowship Award, Leukemia and Lymphoma Society
2006 Young Investigator Award, Ataxia- Telangiectasia Workshop, Banff, Canada
2003 AFLAC Award, American Association for Cancer Research

Research

Research Interests

  • The molecular mechanisms of DNA damage response and their roles in lymphocyte gene-rearrangement

Grants

THE CATALYTIC AND NON-CATALYTIC FUNCTIONS OF PARP1 IN CANCER BIOLOGY (Federal Gov)

Apr 1 2018 - Mar 31 2023

THE STRUCTURAL FUNCTION OF ATR IN DEVELOPMENT, ONCOGENESIS AND CANCER THERAPY (Federal Gov)

Apr 1 2017 - Mar 31 2022

THE ROLE OF ATM IN SUPPRESSION OF LYMOPHOMAS (Federal Gov)

Feb 1 2017 - Jan 31 2022

THE STRUCTURAL FUNCTION OF ATR IN DEVELOPMENT, ONCOGENESIS AND CANCER THERAPY (Private)

Jul 1 2018 - Jun 30 2021

DNA-PKCS PHOSPHORYLATION IN DNA REPAIR AND CHROMOSOMAL TRANSLOCATIONS (Federal Gov)

Dec 1 2014 - Nov 30 2020

DNA DOUBLE-STRAND BREAK REPAIR, CHROMOSOMES TRANSLOCATIONS AND CANCER (Federal Gov)

Apr 1 2014 - Mar 31 2020

CANCER CENTER SUPPORT GRANT (Federal Gov)

Jul 1 2014 - Jun 30 2019

ATM KINASES AS A TUMOR SUPPRESSOR IN DEVELOPING B CELLS (Private)

Jul 1 2013 - Jun 30 2018

THE STRUCTURAL FUNCTION OF ART IN DNA REPLICATION AND TUMORIGENESIS (Private)

Aug 1 2016 - Jul 31 2017

THE KINASE VS STRUCTURE FUNCTION OF ATM IN DNA REPAIR AND TUMOR SUPPRESSION (Private)

Jan 1 2013 - Dec 31 2016

ROLES OF XLF AND 53P1 IN DNA REPAIR AND SUPPRESSION OF LYMPHOMA (Private)

Jul 1 2013 - Jun 30 2016

TARGET ATM MUTATION FOR CANCER THERAPY (Private)

Jan 1 2014 - Dec 31 2015

THE ROLE OF XLF IN HEMATOPOIETIC STEM CELL MAINTENANCE AND FUNCTION (Federal Gov)

Aug 15 2013 - Jul 31 2015

THE ROLE OF ATM KINASE IN SUPPRESSION B CELL LYMPHOMAS (Private)

Jan 1 2012 - Dec 31 2014

THE ROLE OF ATM KINASE ACTIVITY IN THE DEVELOPMENT OF LYMPHOID MALIGNANCY (Private)

Jul 1 2012 - Jun 30 2014

THE MECHANISM OF CLONAL TRANSLOCATIONS IN PEDIATRIC T-ALL: THE ROLE OF ATM (Private)

Jul 1 2010 - Jun 30 2013

THE FUNCTION OF CERNUNNOS IN LYMPHOCYTE DEVELOPMENT AND LYMP HOMAGENESIS (Private)

Dec 1 2009 - Jun 30 2010

Selected Publications

Pinkey KA, Jiang W, Lee BJ, Loredan DG, Li C, Bhagat G and Zha S. Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas. Journal of Hematology & Oncology 2015 Jul 30;8:94. PMID: 26219558

Yamamoto K, Lee BJ, Li C, Dubois RL, Hobeika E, Bhagat G, Zha S. Early B-cell Specific Inactivation of ATM Synergizes with Ectopic CyclinD1 Expression to Promote Pre-germinal center B-cell Lymphomas in Mice. Leukemia. 2015 Jun;29(6):1414-24. PMID: 25676421

Jiang W, Lee BJ, Li C, Dubois R.L, Gostissa M, Alt FW and Zha S. Aberrant TCRδ rearrangement underlies the T cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. 2015 Apr 23;125(17):2665-8. PMID: 25721125.

Jiang W, Crowe J, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S. Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during non-homologous end-joining. Molecular Cell 2015 Apr 2;58(1):172-85 PMID:25818648

Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun. 2015 Feb 11;6:6233. PMID: 25670504

Avagyan S, Churchill M, Yamamoto K, Crowe JL, Li C, Lee BJ, Zheng T, Mukherjee S, Zha S. Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency. Blood 2014 Sep 4;124(10):1622-5. PMID: 25075129

Yamamoto K, Wang Y, Jiang W, Dubois RL, Ludwig T, Lin C, Bakkenist CJ., Zha S. Kinase-Dead ATM protein causes genomic instability and early embryonic lethality in mice. Journal of Cell Biology 2012 Aug 6;198(3):305-13 PMID: 22869596

Liu X, Jiang W, Dubois RL, Yamamoto K, Wolner Z, Zha S. Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development. . 2012 Mar 6;109(10):3903-8. PMID:22413262

Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 2011 Oct 13;118(15):4169-73. Epub 2011 Aug 30. PMID:21878675

Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. . 2011 Feb 1; 108(5):2028-33. PMID: 21245310

Zha S, Guo C, Boboila C, Oksenych V, Cheng H, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff  PH, Dubois RL and Alt FW. XLF Has Functional Redundancy with ATM and H2AX in Non-homologous DNA End-joining. Nature 2011 Jan 13; 469(7329):250-4. PMID:21160472

Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Gatti R, Look AT, AltFW. ATM-Deficient Thymic Lymphoma Is Associated With Aberrant TCR Rearrangement And Gene Amplification. J Exp Med. PMID: 20566716

Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. Lymphocyte-Specific Compensation For XLF/Cernunnos End-Joining Functions In V(D)J Recombination. Mol. Cell. 2008 Sept.5;31(5):631-40. PMID:18775323