Kevin L Gardner, MD, PhD

Board Certifications: 
Pathology - Anatomic
Profile Headshot

Overview

Areas of Expertise / Conditions Treated

  • Clinical Research

Academic Appointments

  • Professor of Pathology & Cell Biology

Administrative Titles

  • Senior Vice Chair, Department of Pathology and Cell Biology

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

  • Male

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Location(s)

Credentials & Experience

Education & Training

  • PhD, Cellular Biology and Anatomy, Johns Hopkins School of Medicine
  • MD, Johns Hopkins School of Medicine
  • Residency: National Institutes of Health
  • Fellowship: Johns Hopkins Hospital

Board Certifications

  • Pathology - Anatomic

Honors & Awards

2015 Office of the Director's Honors Award as part of the Intramural NIH-Wide Diversity Support Team

2011 NIH Director's Award for "for conducting the first research to clearly define a possible molecular mechanism linking metabolic imbalance with increased breast cancer risk"

2010 Emerald Honoree: Research Leadership, Career Communications Group

2007 Nexus Focus, Science Spectrum Magazine, Career Communications Group

2007 NIH Director's Award for "For exceptionally innovative application of both basic and translational approaches to defining the mechanisms of gene regulation and their role in the evolution of cancer"

2005 Invited to attend 2005 Nobel Symposium on "Energy, molecules and the cosmos"

2004 Philip J. Browning Scientific Pioneer Award, NIH Black Scientist Association

2004 National Cancer Institute Technology Transfer Award

2003 Elected member of the American Society for Clinical Investigation (ASCI)

1999 National Cancer Institute EEO Special Achievement Award

1997 National Cancer Institute EEO Officers Recognition Award

1994 National Cancer Institute EEO Officers Recognition Award

1991 National Cancer Institute EEO Officers Recognition Award

1989 Kaiser Merit Scholar

1985 Awarded postdoctoral fellowship by the American Heart Association

1984 William L. Strauss, Jr. Scholarship, Department of Cell Biology and Anatomy, Johns Hopkins School of Medicine

1978 Academic All-American Football Player, CoSIDA

Research

Research Interests

  • Epigenetic regulation in breast cancer

Selected Publications

Singhal SK, Byun JS, Park S, Yan T, Yancey R, Caban A, Gil Hernandez S, Hewitt SM, Boisvert H, Hennek S, Bobrow M, Ahmed S, White J, Yates C, Aukerman A, Vanguri R, Bareja R, Lenci R, Farré PL, De Siervi A, Napoles AM, Vohra NA, &Gardner K, The subcellular partitioning of Kaiso (ZBTB33) is functionally linked to LC3A/B, the tumor microenvironment, and overall breast cancer survival.Communications biology. (In Press)

Pérez-Stable E, Dankwa-Mullan I,Gardner K, Zhang X, & Rosario AM.The Science of Health Disparities Research.1stEd. Hoboken, NJ. Wiley-Blackwell, (2021) 528p.

Bisogno LS, Yang J, Bennett BD, Ward JM, MacKey LC, Annab LA, Bushel PR, Singhal S, Schurman SH, Byun JS, Nápoles AM, Pérez-Stable EJ, Fargo DC,Gardner K, & Archer TK. Ancestry-dependent gene expression correlates with reprogramming to pluripotency and multiple dynamic biological processes.Sci Adv.Nov;6(47). (2020). PMCID: PMC7679169

Arauz RF, Byun JS, Tandon M, Sinha S, Kuhn S, Taylor S, Zingone A, Mitchell KA, Pine SR,Gardner K, Perez-Stable EJ, Napoles AM, & Ryan BM, Whole Exome Profiling of NSCLC Among African Americans.J Thorac Oncol.Sep 12;S1556-0864(20)30721-8 (2020).

Davis M, Martini R, Newman L, Elemento O, White J, Verma A, Datta I, Adrianto I, Chen Y,Gardner K, Kim HG, Colomb WD, Eltoum IE, Frost AR, Grizzle WE, Sboner A, Manne U, Yates C, Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations.CancersMay 13; 12(5):1220 (2020). PMCID: PMC7281131

Byun JS, Singhal SK, Park S, Yi DI, Yan T, Caban A, Jones A, Mukhopadhyay P, Gil SM, Hewitt SM, Newman L, Davis MB, Jenkins BD, Sepulveda JL, De Siervi A, Nápoles AM, Vohra NA,Gardner K, Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival.Clin Cancer ResApril 15; 26(8):1905-191 PMID: 31911546 (2020).

Singhal SK, Byun JS, Park S, Yan T, Yancey R, Caban A, Gil Hernandez S, Hewitt SM, Boisvert H, Hennek S, Bobrow M, Ahmed S, White J, Yates C, Aukerman A, Vanguri R, Bareja R, Lenci R, Farré PL, De Siervi A, Napoles AM, Vohra NA, & Gardner K, The subcellular partitioning of Kaiso (ZBTB33) is functionally linked to LC3A/B, the tumor microenvironment, and overall breast cancer survival.Communications biology. (In Press)

Perez-Stable E, Dankwa-Mullan I, Gardner K, Zhang X, & Rosario AM. The Science of Health Disparities Research. 1st Ed. Hoboken, NJ. Wiley-Blackwell, (2021) 528p.

Bisogno LS, Yang J, Bennett BD, Ward JM, MacKey LC, Annab LA, Bushel PR, Singhal S, Schurman SH, Byun JS, Nápoles AM, Pérez-Stable EJ, Fargo DC, Gardner K, & Archer TK. Ancestry-dependent gene expression correlates with reprogramming to pluripotency and multiple dynamic biological processes. Sci Adv. Nov;6(47). (2020). PMCID: PMC7679169

Arauz RF, Byun JS, Tandon M, Sinha S, Kuhn S, Taylor S, Zingone A, Mitchell KA, Pine SR, Gardner K, Perez-Stable EJ, Napoles AM, & Ryan BM, Whole Exome Profiling of NSCLC Among African Americans. J Thorac Oncol. Sep 12;S1556-0864(20)30721-8 (2020).

Davis M, Martini R, Newman L, Elemento O, White J, Verma A, Datta I, Adrianto I, Chen Y, Gardner K, Kim HG, Colomb WD, Eltoum IE, Frost AR, Grizzle WE, Sboner A, Manne U, Yates C, Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations. Cancers May 13; 12(5):1220 (2020). PMCID: PMC7281131

Byun JS, Singhal SK, Park S, Yi DI, Yan T, Caban A, Jones A, Mukhopadhyay P, Gil SM, Hewitt SM, Newman L, Davis MB, Jenkins BD, Sepulveda JL, De Siervi A, Nápoles AM, Vohra NA, Gardner K, Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival. Clin Cancer Res April 15; 26(8):1905-191 PMID: 31911546 (2020).

Byun JS, Park S, Caban A, Jones A, Gardner K. Linking Race, Cancer Outcomes and Tissue Repair.Am J Pathol. 2017 Nov 11. pii: S0002-9440(17)30629-6. [Epub ahead of print]

Gardner K. The Science of Cancer Health Disparities. Am J Pathol. 2017 Nov 11. pii: S0002-9440(17)30704-6. [Epub ahead of print]

Bassey-Archibong BI, Hercules SM, Rayner LGA, Skeete DHA, Smith Connell SP, Brain I, Daramola A, Banjo AAF, Byun JS, Gardner K, Dushoff J, Daniel JM: Kaiso is highly expressed in TNBC tissues of women of African ancestry compared to Caucasian women. Cancer Causes Control Sep 8. doi: 10.1007/s10552-017-0955-2 (2017).

Fufa TD, Byun JS, Wakano C, Fernandez AG, Pise-Masison CA, Gardner K, The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription. Biochemical and biophysical research communications 465, 5-11 (2015).

Di LJ, Byun JS, Wong MM, Wakano C, Taylor T, Bilke S, Baek S, Hunter K, Yang H, Lee M, Zvosec C, Khramtsova G, Cheng F, Perou CM, Miller CR, Raab R, Olopade OI, Gardner K, Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nature communications 4, 1449 (2013).

Byun JS, Fufa TD, Wakano C, Fernandez A, Haggerty CM, Sung MH, Gardner K, ELL facilitates RNA polymerase II pause site entry and release. Nature communications 3, 633 (2012).

Di LJ, Fernandez AG, De Siervi A, Longo DL, Gardner K, Transcriptional regulation of BRCA1 expression by a metabolic switch.Nature structural & molecular biology 17, 1406-1413 (2010).

De Siervi A, De Luca P, Byun JS, Di LJ, Fufa T, Haggerty CM, Vazquez E, Moiola C, Longo DL, Gardner K, Transcriptional autoregulation by BRCA1. Cancer Research 70, 532-542 (2010).

Byun JS, Wong MM, Cui W, Idelman G, Li Q, De Siervi A, Bilke S, Haggerty CM, Player A, Wang YH, Thirman MJ, Kaberlein JJ, Petrovas C, Koup RA, Longo D, Ozato K, Gardner K, Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proceedings of the National Academy of Sciences of the United States of America 106, 19286-19291 (2009).