Keiichi Inoue, PhD

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Overview

Email: ki2139@cumc.columbia.edu

Academic Appointments

  • Assistant Professor of Pathology & Cell Biology at CUMC

Research

Analyses of basic mechanism of neurodegenerative disorders and establishment of disease models.

Research Interests

  • Analyses of basic mechanism of neurodegenerative disorders and establishment of disease models

Selected Publications

Kuwahara T, Inoue K, D'Agati VD, Fujimoto T, Eguchi T, Saha S, Wolozin B, Iwatsubo T, Abeliovich A. LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. Sci Rep. 2016 Jul 18;6:29945. doi: 10.1038/srep29945. PMID: 27424887

Qiang L, Inoue K, Abeliovich A. Instant neurons: directed somatic cell reprogramming models of central nervous system disorders. Biol Psychiatry. 2014 Jun 15;75(12):945-51. doi: 10.1016/j.biopsych.2013.10.027. Review. PMID: 24525100

Inoue K, Rispoli J, Yang L, Macleod D, Beal MF, Klann E, Abeliovich A. Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway. PLoS Genet. 2013;9(10):e1003845. doi: 10.1371/journal.pgen.1003845. PMID: 24098148

Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R, Guarnieri P, Bhagat G, Vanti WB, Shih A, Levine RL, Nik S, Chen EI, Abeliovich A. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature. 2012 Aug 30;488(7413):652-5. doi: 10.1038/nature11333. PMID: 22902501

Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012 Sep 21;7:48. doi: 10.1186/1750-1326-7-48. PMID: 22998728

Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A. A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 2007 Aug 31;317(5842):1220-4. PMID: 17761882

Inoue K, Mikuni-Takagaki Y, Oikawa K, Itoh T, Inada M, Noguchi T, Park JS, Onodera T, Krane SM, Noda M, Itohara S. A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J Biol Chem. 2006 Nov 3;281(44):33814-24. PMID: 16959767