Jaewon Min, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Pathology and Cell Biology (in the Institute for Cancer Genetics)

Gender

  • Male

Credentials & Experience

Honors & Awards

  • 2003 – 2007  National Science & Technology Scholarship<</li>
  • 2009 – 2011  Hi-Seoul Science Fellowship
  • 2014 – 2016  CPRIT Postdoctoral Cancer Intervention and Prevention Discovery Training Program
  • 2017 – 2019  NIH/NCI T32 Cancer Research Training Program
  • 2021 –           NIH/NCI K22 Career Transition Award

Research

My overall goal as a cancer cell biologist is to decipher the cellular and molecular phenomena that occur in cancer to facilitate the development of new ways to prevent, diagnose and treat cancer. I have been studying the telomere maintenance mechanism that is essential for the initiation and progression of cancer. I have focused on the alternative lengthening of telomeres (ALT) pathway, a telomerase-independent telomere maintenance mechanism that frequently occurs in mesenchymal origin human cancers (i.e., sarcomas, endocrine tumors, and soft tissue cancers- brain tumors; glioblastoma and in a subset of pediatric cancers, neuroblastoma). I have uncovered novel molecular mechanisms underlying ALT pathway from my series of published studies. The Min laboratory (Telomere biology Lab) will identify how cancer cells acquire telomere maintenance mechanisms independent of telomerase during tumorigenesis and how to target such telomere maintenance mechanisms as an anti-cancer strategy.

Selected Publications

  • Min, J., and Shay, J.W. (2019) Telomere clustering drives ALT. Aging (Albany NY). 11:8046-9047 (Editorial article) PubMed PMID: 31612868
  • Min, J., Wright, W.E. and Shay, J.W. (2019) Clustered Telomeres in Phase-Separated Nuclear Condensates Engage Mitotic DNA Synthesis through BLM and RAD52. Genes Dev. Jul 1;33(13-14):814-827. doi: 10.1101/gad.324905.119. PubMed PMID: 31171703 
    a) Cover image in Genes & Development July 1, 2019
    b) Spotlighted by Flynn, R.L. and Heaphy C.M. (2019) Surviving telomere attrition with the MiDAS touch. Trends Genet. doi: 10.1016/j.tig.2019.08.008. PubMed PMID: 31526614  
  • Min, J., Wright, W.E. and Shay, J.W. (2017) Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Mol. Cell. Biol. 26;37(20) doi:10.1128/MCB.00226-17. PubMed PMID: 28760773
  • Min, J., Wright, W.E. and Shay, J.W. (2017) Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Res. 10.1093/nar/gkw1295. PubMed PMID: 28082393

For a complete list of publications, please visit https://www.ncbi.nlm.nih.gov/myncbi/1RohtWsUK9H9vg/bibliography/public/