Huai-bin M Ko, MD, MS

Pathology - Anatomic
Accepting New Patients
Treats Children
Profile Headshot


Areas of Expertise / Conditions Treated

  • Gastrointestinal Pathology

Academic Appointments

  • Associate Professor of Pathology and Cell Biology at CUMC

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Female

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Credentials & Experience

Education & Training

  • MD Doctor of Medicine, Mount Sinai School of Medicine
  • Residency: 2014 Mount Sinai Medical Center
  • Fellowship: Icahn School of Medicine at Mount Sinai

Board Certifications

  • Pathology-Anatomic/Pathology-Clinical


Selected Publications

  • Liu Q, Zhang X, Ko HM, Stocker D, Ellman J, Chen J, Hao Y, Bhardwaj S, Liang Y, Cho J, Colombel JF, Taouli B, Harpaz N. Constrictive and Hypertrophic Strictures in Ileal Crohn's Disease. Clin Gastroenterol Hepatol. 2021 Aug 14:S1542-3565(21)00868-5. doi: 10.1016/j.cgh.2021.08.012. PMID: 34400338.
  • Choi WT, Salomao M, Zhao L, Alpert L, Setia N, Liao X, Drage MG, Westerhoff M, Cheng J, Lauwers GY, Ko HM. Hypermucinous, Goblet Cell Deficient, and Crypt Cell Dysplasias in Inflammatory Bowel Disease are Often Associated with Flat/Invisible Endoscopic Appearance and Advanced Neoplasia on Follow-Up. J Crohns Colitis. 2021 Jul 7:jjab120. doi: 10.1093/ecco-jcc/jjab120. PMID: 34232295.
  • Ko HM. Baseline histological findings do not predict the risk of subsequent extension in patients with limited ulcerative colitis. Dig Dis Sci.2021 May 2. doi: 10.1007/s10620-021-06970-y. PMID: 33934255.
  • Yilmaz MM, Martinez M, Ko HM. Gastrointestinal Manifestations of a Rare Lipid Storage Disorder. Gastroenterology. 2021 Feb 17:S0016-5085(21)00420-0. doi: 10.1053/j.gastro.2021.02.032. PMID: 33609508.
  • Lee M, Kudose S, Del Portillo A, Ko HM, Lee H, Pittman ME, Salomao MA, Sepulveda AR, Lagana SM. Invasive carcinoma versus pseudoinvasion: interobserver variability in the assessment of left-sided colorectal polypectomies. J Clin Pathol. 2021 Apr 12:jclinpath-2021-207406. doi: 10.1136/jclinpath-2021-207406. PMID: 33846218.
  • Nayar S, Morrison JK, Giri M, Gettler K, Chuang LS, Walker LA, Ko HM, Kenigsberg E, Kugathasan S, Merad M, Chu J, Cho JH. A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease. Nature. 2021 Mar 31. doi: 10.1038/s41586-021-03484-5. PMID: 33789339.
  • Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, Parigi TL, Ladinsky MS, Ramos I, Dunleavy K, Lee B, Dixon R, Chen ST, Martinez-Delgado G, Nagula S, Bruce EA, Ko HM, Glicksberg BS, Nadkarni G, Pujadas E, Reidy J, Naymagon S, Grinspan A, Ahmad J, Tankelevich M, Bram Y, Gordon R, Sharma K, Houldsworth J, Britton GJ, Chen-Liaw A, Spindler MP, Plitt T, Wang P, Cerutti A, Faith JJ, Colombel JF, Kenigsberg E, Argmann C, Merad M, Gnjatic S, Harpaz N, Danese S, Cordon-Cardo C, Rahman A, Schwartz RE, Kumta NA, Aghemo A, Bjorkman PJ, Petralia F, van Bakel H, Garcia-Sastre A, Mehandru S. Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms. Gastroenterology. 2021 Mar 3:S0016-5085(21)00461-3. doi: 10.1053/j.gastro.2021.02.056. PMID: 33676971; PMCID: PMC7931673.
  • Alpert L, Setia N, Ko HM, Lagana SM, Pittman ME, Johncilla M, Drage MG, Zhao L, Salomao MA, Liao X, Choi WT, Jenkins SM, Hart J, Harpaz N, Voltaggio L, Lauwers GY, Odze R, Remotti H, Smyrk TC, Graham RP. Interobserver agreement and the impact of mentorship on the diagnosis of inflammatory bowel disease-associated dysplasia among subspecialist gastrointestinal pathologists. Virchows Arch. 2021 Jan 3. doi: 10.1007/s00428-020-02998-z. PMID: 33392796.
  • Suárez-Fariñas M, Tokuyama M, Wei G, Huang R, Livanos A, Jha D, Levescot A, Irizar H, Kosoy R, Cording S, Wang W, Losic B, Ungaro R, Di'Narzo A, Martinez-Delgado G, Suprun M, Corley MJ, Stojmirovic A, Houten SM, Peters L, Curran M, Brodmerkel C, Perrigoue J, Friedman JR, Hao K, Schadt EE, Zhu J, Ko HM, Cho J, Dubinsky MC, Sands BE, Ndhlovu L, Cerf-Bensusan N, Kasarskis A, Colombel JF, Harpaz N, Argmann C, Mehandru S. Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease. Gastroenterology. 2020 Sep 24:S0016-5085(20)35210-0. doi: 10.1053/j.gastro.2020.09.029.
  • Lee M, Ko HM, Rubino A, Lee H, Gill R, Lagana SM. Malakoplakia of the Gastrointestinal Tract: Clinicopathologic Analysis of 23 Cases. Diagn Pathol. 2020 Jul;15(1):97. DOI: 10.1186/s13000-020-01013-y<</li>
  • Sifers T, Hirten R, Mehandru S, Ko HM, Colombel JF, Cunningham-Rundles C. Vedolizumab therapy in common variable immune deficiency associated enteropathy: A case series. Clin Immunol. 2020 Feb 11;212:108362.
  • Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, Sanchez E, Chen H, Radigan L, Berenson J, Cunningham-Rundles C. Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies.J Allergy Clin Immunol Pract. 2020 Jan;8(1):283-291.e1.
  • Harpaz N, Ballentine S, Colombel JF, E Sands B, Ko HM. Microscopic heterogeneity in ulcerative colitis: implications for microscopic measurement of disease activity. Gut. 2019 Feb 5.
  • Martin JC, Chang C, Boschetti G, Ungaro R, Giri M, Grout JA, Gettler K, Chuang LS, Nayar S, Greenstein AJ, Dubinsky M, Walker L, Leader A, Fine JS, Whitehurst CE, Mbow ML, Kugathasan S, Denson LA, Hyams JS, Friedman JR, Desai PT, Ko HM, Laface I, Akturk G, Schadt EE, Salmon H, Gnjatic S, Rahman AH, Merad M, Cho JH, Kenigsberg E. Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Cell. 2019 Sep 5;178(6):1493-1508.e20. doi: 10.1016/j.cell.2019.08.008.
  • Maglione PJ, Gyimesi G, Cols M, Radigan L, Ko HM, Weinberger T, Lee BH, Grasset EK, Rahman AH, Cerutti A, Cunningham-Rundles C. BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency. JCI Insight.2019 Mar 7;4(5). pii: 122728. doi: 10.1172/jci.insight.122728.
  • Uzzan M, Tokuyama M, Rosenstein AK, Tomescu C, SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley MJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, Mehandru S. Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Sci Transl Med. 2018;10(461):4711.
  • Zhang X*,Ko HM*, Torres J, Panchal HJ, Can Z, Wagner M, Sands B, Colombel JF, Cho J, Taouli B, Harpaz N. Luminally-polarized mural and vascular remodeling in ileal strictures of Crohn’s Disease. Hum Pathol. 2018 Mar 16. [* co-first authors]
  • Wagner M, Ko HM, Chatterji M, Besa C, Torres J, Zhang X, Panchal H, Hectors S, Cho J, Colombel JF, Harpaz N, Taouli B. Magnetic resonance imaging predicts histopathologic composition of ileal Crohn’s disease. J Crohn’s Colitis. 2018 Jan 02. doi: 10.1093/ecco-jcc/jjx186.
  • Uzzan M, Ko HM, Rosenstein AK, Pourmand K, Colombel JF, Mehandru S. Efficient long-term depletion of CD20+ B cells by rituximab does not affect gut-resident plasma cells. Ann NY Acad Sci. 2018 Mar;1415(1):5-10. doi: 10.1111/nyas.13577.
  • Namagon S, Naymagon L, Wong S. Ko HM, Renteria A, Levine J, Colombel JF, Ferrara J. Acute graft-versus-host-disease of the gut: considerations for the gastroenterologist. Nat Rev Gastroenterol Hepatol. 2017 Sep 27. doi: 10.1038/nrgastro.2017.126.
  • He Z, Chen L, Souto FO, Canasto-Chibuque C, Bongers G, Deshpande M, Harpaz N, Ko HM, Kelley K, Furtado GC, Lira SA. Epithelial-derived IL-33 promotes intestinal tumorigenesis in App Min/+ mice. Scientific Reports. 2017 July(7). doi:10.1038/s41598-017-05716-z
  • Chen M, Ko HM, Riffle ME, Andreae DA, Cunningham-Rundles C, Chehade M, Maglione PJ. Eosinophilic Esophagitis Diagnosed in a Patient with Common Variable Immunodeficiency. J Allergy Clin Immunol. 2016 Sep-Oct;4(5):995-7. doi:10.1016/j.jaip.2016.03.023
  • Uzzan M, Ko HM, Mehandru S, Cunningham-Rundles C. Gastrointestinal Disorders Associated with Common Variable Immune Deficiency (CVID) and Chronic Granulomatous Disease (CGD). Curr Gastroenterol Rep.2016 Apr;18(4):17.doi:10.1007/s11894-016-0491-3
  • Ruel J, Ko HM, Roda G, Patil N, Zhang D, Jharap B, Harpaz N, Colombel JF. Anal Neoplasia in Inflammatory Bowel Disease is Associated with HPV and Perianal Disease. Clin Transl Gastroenterol. 2016 Mar 3;7:e148. doi: 10.1038/ctg.2016.8.
  • Ko HM, Harpaz N, McBride RB, Cui M, Ye F, Zhang D, Ullman TA, Polydorides AD. Serrated Colorectal Polyps in Inflammatory Bowel Disease. Modern Pathology 2015;28:1584-1593.
  • Harpaz N, Ko HM. CVID Associated Enteropathy in a 47-year-old Woman. Digest Endosc 2015;27:414-5.
  • Cols M, Rahman A, Maglione PJ, Garcia-Carmona Y, Simchoni N, Ko HM, Radigan L, Cerutti Am Blankenship D, Pascual V, Cunningham-Rundles C. Expansion of inflammatory innate lymphoid cells in patients with common variable immunodeficiency. J Allergy Clin Immunol. 2015 Nov 2. pii: S0091-6749(15)01351-2
  • Kaplan-Lewis E, Robins D, Welinsky S, Lee M, MacKay R, Ko M, Zhu H, Hamula CLA. Disseminated cryptococcosis presenting as perforated appendicitis and initially misdiagnosed as histoplasmosis. Infect Dis Clin Pract 2015;00:00-00.
  • Ko HM, Morotti RA, Yershov O, Chehade M. Eosinophilic Gastritis in Children: Clinicopathological Correlation, Disease Course, and Response to Therapy. Am J Gastroenterol. 2014 Aug;109(8):1277-1285.
  • Dhingra S, Schwartz M, Kim E, Ko HM, Ward SC, Fiel M, Thung SN. Histological Changes in Nontumoral Liver Secondary to Radioembolization of Hepatocellular Carcinoma with Yttrium 90-impregnated Microspheres: Report of Two Cases. Semin Liver Dis. 2014 Nov;34(4):465-8
  • Harpaz N, Taboada S, Ko HM, Yu J, Yang Q, Xu H, Cao W. Expression of MACC1 and MET in inflammatory bowel disease-associated colonic neoplasia. Inflamm Bowel Dis. 2014  Apr;20(4):703-11.
  • Maglione PJ, Ko HM, Beasley MB, Strauchen JA, Cunningham-Rundles C. Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency. J Allergy Clin Immunology. 2014 Feb;133(2):535-42.
  • Ko H, Perl D, Krieger S, Karani R, Fallar R, Schindler M, Magid M. Online Case Study: The Clinical and Pathological Differential Diagnosis of Encephalopathy ("The Mysterious case of 'John Doe'"). MedEdPORTAL; 2013. Available from:
  • Ko HB, Lento PA, Morotti R. Acute Rheumatic Fever. Autopsy Pathology Program 2013. Northfield, IL: College of American Pathologists.
  • Xiao GQ, Ko HB, Unger P. Telangiectatic oncocytoma: a previously undescribed variant of renal oncocytoma. Am J Clin Pathol. 2013 Jul;140(1):103-8.
  • Hechtman JF, Beasley MB, Kinoshita Y, Ko HM, Hao K, Burstein DE. Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors: a pilot immunohistochemical study.  Hum Pathol. 2013 Jul;44(7):1400-5.
  • Ko HM, Hernandez JC, Zhu H, Dikman S, Sidhu HK, Ward SC, Thung SN. Morphologic features of extrahepatic manifestations of Hepatitis C virus infection. Clin Dev Immunol. 2012:740138.
  • Schecterson LC, Hudson MP, Ko M, Philippidou P, Akmentin W, Wiley J, Rosenblum E, Chao MV, Halegoua S, Bothwell M. Trk activation in the Secretory Pathway Promotes Golgi Fragmentation. Mol Cell Neurosci. 2010 Apr;43(4):403-13. doi: 10.1016