David W. Dempster, PhD, FRMS

  • Professor Emeritus of Clinical Pathology and Cell Biology
Profile Headshot


David W. Dempster, BSc (Hons), PhD, FRMS is Professor of Clinical Pathology and Cell Biology at Columbia University in New York and a Senior Research Fellow at the Regional Bone Center of Helen Hayes Hospital, West Haverstraw, New York. He received a First Class Honors degree and a PhD from the University of Glasgow in Scotland and completed postdoctoral studies in Switzerland and France.

Dr. Dempster is a Past President of the International Society of Bone Morphometry and has served on the Scientific Advisory Council of the National Osteoporosis Foundation. He is a Fellow of the Royal Microscopical Society. Dr. Dempster’s iconic micrographs of osteoporotic bone have been widely reproduced in the scientific and popular press, including being displayed at the Smithsonian Institution in Washington, DC.

Dr. Dempster is an Associate Editor of Osteoporosis International, and serves on the editorial boards of the Journal of Bone and Mineral Research, Bone and the Journal of Clinical Densitometry. His research studies have been continuously supported by the National Institutes of Health for the past 30 years. Dr. Dempster has published over 200 research papers on the pathophysiology and treatment of bone disease. He is the Editor in Chief of the upcoming Vth edition of the highly respected textbook Osteoporosis (affectionately known as “Big Red”)

Dr. Dempster holds a black belt in taekwondo and is an active member of Rotary International and a Paul Harris Fellow.

Email: ddempster9@aol.com

Academic Appointments

  • Professor Emeritus of Clinical Pathology and Cell Biology


  • Male

Credentials & Experience

Education & Training

  • BS, PhD, 1979 Physiology (Bone Metabolism), University of Glasgow

Honors & Awards

2019 - Editor-in-Chief, Osteoporosis (“Big Red”), Vth Edn.

2016 - Dr. Aurelio Rapada Memorial Lecture, “From Classical Histomorphometry to the Present” October 21, Gran Canaria, Spain.

2015 - Presenter, First joint webinar sponsored by the European Calcified Tissue Society (ECTS), the International Bone and Mineral Society (IBMS) and Nature.com. “Cortical Bone Modeling and Remodeling in the Adult Skeleton,” Live broadcast”, September 17th, 2015.

2015 - Speaker and panelist, First International Conference on the Diagnosis, Management and Treatment of Hypoparathyroidism, Florence, Italy, May 8th, 2015.

2013 - Speaker and Panelist, Fourth International Workshop on the Management of Asymptomatic Primary Hyperpara-thyroidism, Florence, Italy, September 19-21, 2013.

2013 - Visiting Professor, King’s College, Cambridge, April 15, 2013

2012 - Chairperson, 2012 Update of ASBMR Report on Standardized Nomenclature, Symbols and Units for Bone Histomorphometry

2013 - Co-editor, Osteoporosis (“Big Red”) IVth Edition, Elsevier

2011 - The First SIGMA Distinguished Lecture, Vancouver, Canada, December 8, 2011. "Bone Turnover: the Good, the Bad and the Ugly"

2010 and 2012 - Member, ASBMR Task Force on Atypical Subtrochanteric and Diaphyseal Fractures

2010 - The Louis V. Avioli Bone Lecture, Washington University, St Louis, May 14, 2010. “PTH: Feast or Famine; An Histomorphometrist’s View”

2008 - Member, ASBMR Task Force on Bisphosphonate-Associated Osteonecrosis of the Jaw

2008 - Member, Canadian Consensus Panel on Practice Guidelines for Bisphosphonate-Associated Osteonecrosis of the Jaw

2008 - Member, Expert Panel: Defining Fractures Attributable to Osteoporosis, University of Alabama

2007 to 2010 - Member, Advisory Group for NIAMS U01 “HR-pQCT as a biomarker of bone strength in osteoporosis trials.

2006 - Guest Editor, Clinical Reviews in Bone and Mineral Metabolism, Humana Press.

2005 t present - Member, Scientific Advisory Council of the National Osteoporosis Foundation

2004 - Images from this article appeared in the first U.S. Surgeon General’s Report on Bone Health and Osteoporosis

2003 to present - Elected Member, Association of Osteobiology

2003 - 1986 paper “A simple method for correlative light and scanning electron microscopy of human iliac crest bone biopsies” selected as one of the 21 most influential papers to be published in the first 10 years of the JBMR

2001 to 2002 - Member, Education Committee of the American Society for Bone & Mineral Research

2000 - New York State Department of Health Award of Excellence

2000 to 2003 - Member, National Osteoporosis Foundation’s Continuing Medical Education Committee

2000 to 2002 - Founding Member, Board of Directors, International Society of Musculoskeletal and Neuronal Interactions

1996 to 1999 - Honorary Member, International Chinese Hard Tissue Society

1999-present - President, International Society of Bone Morphometry http://www.bonemorphometry.com/index.html

1991 to 1997 - Member, Scientific Advisory Board of the National Osteoporosis Foundation

1988 to 1989 - Member, Public Affairs and Development Committee, American Society for Bone & Mineral Research


Selected Publications

Paschalis EP, Gamsjaeger S, Dempster D, Jorgetti V, Borba V, Boguszewski CL, Klaushofer K, Moreira CA. Fragility Fracture Incidence in Chronic Obstructive Pulmonary Disease (COPD) Patients Associates with Nanoporosity, Mineral/Matrix Ratio, and Pyridinoline Content at Actively Bone Forming Trabecular Surfaces. J Bone Miner Res. 2016 Aug 4. doi: 10.1002/jbmr.2933. [Epub ahead of print] PubMed PMID: 27490957.

Shoback DM, Bilezikian JP, Costa AG, Dempster D, Dralle H, Khan AA, Peacock M, Raffaelli M, Silva BC, Thakker RV, Vokes T, Bouillon R. Presentation of Hypoparathyroidism: Etiologies and Clinical Features. J Clin Endocrinol Metab. 2016 Jun; 101(6):2300-12.

Cosman F, Nieves JW, Dempster D. Treatment Sequence Matters: Anabolic and Antiresorptive Therapy for Osteoporosis. J Bone Miner Res. 2016 Dec 7. doi: 10.1002/jbmr.3051. [Epub ahead of print]

Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster J-Y, Roux C, Malouf J, Bradley MN, Daizadeh N, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S Ten Years of Denosumab Treatment in Postmenopausal Women With Osteoporosis: Results From the Phase 3 Randomized FREEDOM Trial and the Open-label Extension. Lancet Diabetes Endocrinol. 2017 May 22. pii: S2213-8587(17)30138-9. doi: 10.1016/S2213-8587(17)30138-9. [Epub ahead of print]

Fan Y, Hanai J-I, Ruiye B, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian, Dempster DW, JP, Rosen CJ, Lanske B. Parathyroid hormone directs marrow mesenchymal cell fate. Cell Metabolism 2017;25:1-12.

Cohen A, Kousteni S, Bisikirska B, Shah JG, Manavalan JS, Recker RR, Lappe J, Dempster DW, Zhou H, McMahon DJ, Bucovsky M, Kamanda-Kosseh M, Stubby J, Shane E. IGF-1 Receptor Expression on Circulating Osteoblast Progenitor Cells Predicts Tissue-based Bone Formation Rate and Response to Teriparatide in Premenopausal Women with Idiopathic Osteoporosis. J Bone Miner Res. 2017 Feb 20. doi:10.1002/jbmr.3109. [Epub ahead of print]

Dempster DW. Tethering Formation to Resorption: Reversal Revisited. J Bone Miner Res. 2017 May 12. doi: 10.1002/jbmr.3169. [Epub ahead of print] PubMed PMID: 28498616.

Cosman F, Nieves JW, Dempster DW. Response to Letter to the Editor of JBMR: Treatment Sequence Matters. J Bone Miner Res. 2017 May;32(5):1148-1150. doi:10.1002/jbmr.3126. Epub 2017 Apr 14. PubMed PMID: 28294411.

Moreira CA, Dempster DW. Histomorphometric changes following treatment for osteoporosis. J Endocrinol Invest. 2017 May 26. doi: 10.1007/s40618-017-0662-6. [Epub ahead of print] PubMed PMID: 28550463.

Cosman F, Nieves JW, Dempster DW. Response to Letter to the Editor of JBMR: Treatment Sequence Matters. J Bone Miner Res. 2017 May;32(5):1148-1150

Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Melby TE, Ruff VA. Remodeling- and Modeling-Based Bone Formation with Teriparatide versus Denosumab: A Longitudinal Analysis from Baseline to 3 Months in the AVA Study. J Bone Miner Res. 2017 Oct 12. doi: 10.1002/jbmr.3309. [Epub ahead of print]

Books and Monographs

Lindsay R, Dempster DW, Jordan CV (eds) Estrogens and Anti-estrogens: Basic and Clinical Aspects, Lipincott-Raven Publishers, Philadelphia-New York, 1997.

Dempster DW, Felsenberg D, van der Geest S (eds). The Bone Quality Book, Elsevier BV, Amsterdam, The Netherlands , 2006.

Marcus R, Feldman D, Dempster DW, Luckey M, Cauley J (Eds), Osteoporosis ("Big Red") IVth Edition, Elsevier, 2013.

Dempster DW, Bouxsein M, Cauley J, Cosman C (Eds) Osteoporosis ("Big Red") Vth Edition, Elsevier, 2018.