Andrew F. Teich, MD, PhD

Neuropathology
Pathology - Anatomic
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Overview

Laboratory website: Teich Lab

Academic Appointments

  • Associate Professor of Pathology and Cell Biology (in Neurology)

Administrative Titles

  • Director of the New York Brain Bank

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

  • Male

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Credentials & Experience

Education & Training

  • Columbia University College of Physicians and Surgeons
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Board Certifications

  • Neuropathology
  • Anatomic Pathology

Honors & Awards

  • 2016 Paul B. Beeson Emerging Leaders Career Development Award in Aging, NIH-NIA
  • 2014 Margaret M. Cahn Research Award, Alzheimer’s Association
  • 2011 Louis V. Gerstner, Jr. Scholar Award, Louis V. Gerstner, Jr. Scholar Foundation/Columbia University

Research

Our laboratory uses human brain tissue specimens and human cell-derived model systems to study the pathogenesis of Alzheimer’s disease (AD) and identify viable therapeutic targets.  I am also the Director of the New York Brain Bank, and we are using tissue specimens from this repository to better understand the heterogeneity of AD pathology and how this may impact clinical presentation.  We use a broad range of computational and molecular techniques, and collaborate extensively with other PIs at CUIMC.

Welcome to Teich Lab!

 

Selected Publications

  • Bartosch, A.M.W., E.H.H. Youth, S. Hansen, Y. Wu, H.M. Buchanan, M.E. Kaufman, H. Xiao, S.Y. Koo, A. Ashok, S. Sivakumar, R.K. Soni, L.C. Dumitrescu, T.G. Lam, A.S. Ropri, A.J. Lee, H.U. Klein, B.N. Vardarajan, D.A. Bennett, T.L. Young-Pearse, P.L. De Jager, T.J. Hohman, A.A. Sproul, and A.F. Teich, ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease. J Neurosci, 2024. 44(3).PMC10860597.
  • Cortese, G.P., A.M.W. Bartosch, H. Xiao, Y. Gribkova, T.G. Lam, E.K. Argyrousi, S. Sivakumar, C. Cardona, and A.F. Teich, ZCCHC17 knockdown phenocopies Alzheimer's disease-related loss of synaptic proteins and hyperexcitability. J Neuropathol Exp Neurol, 2024. 10.1093/jnen/nlae033.
  • Ropri, A.S., T.G. Lam, V. Kalia, H.M. Buchanan, A.M.W. Bartosch, E.H.H. Youth, H. Xiao, S.K. Ross, A. Jain, J.K. Chakrabarty, M.S. Kang, D. Boyett, E.F. Spinazzi, G. Iodice, R.A. McGovern, L.S. Honig, L.M. Brown, G.W. Miller, G.M. McKhann, and A.F. Teich, Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression. Alzheimers Dement, 2024. 10.1002/alz.14194
  • Huang, W., A.M. Bartosch, H. Xiao, S. Maji, E.H.H. Youth, X. Flowers, S. Leskinen, Z. Tomljanovic, G. Iodice, D. Boyett, E. Spinazzi, V. Menon, R.A. McGovern, G.M. McKhann, and A.F. Teich, An immune response characterizes early Alzheimer's disease pathology and subjective cognitive impairment in hydrocephalus biopsies. Nat Commun, 2021. 12(1): p. 5659.
  • Tomljanovic, Z., M. Patel, W. Shin, A. Califano, and A.F. Teich, ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer's disease. Bioinformatics, 2018. 34(3): p. 367-371.

For a complete list of publications, please visit PubMed.gov