Tiffany Thomas, PhD

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Overview

Dr. Tiffany A. Thomas Ph.D. is an assistant professor in the department of Pathology and Cell Biology. She is the director of the New York Presbyterian Hospital Biochemical Genetics Laboratory. The laboratory performs metabolic profile testing (amino acid, organic acid, and acylcarnitine profiles) for patients with suspected metabolic diseases including inborn errors of metabolism as well as acquired metabolic disorders. The metabolite profiles provide important diagnostic and prognostic information, as well as guidance for the lifelong dietary management of patients with inborn errors of metabolism

In addition to Dr. Thomas' clinical responsibilities, she is also a member of the CUMC Institute of Human Nutrition teaching faculty. She also has a research interest in using stable isotopes to understand impaired flux through metabolic pathways associated with acquired and inherited diseases.

Academic Appointments

  • Assistant Professor of Pathology & Cell Biology at CUMC

Administrative Titles

  • Director, Biochemical Genetics Laboratory

Gender

  • Female

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Credentials & Experience

Education & Training

  • BS, 2000 Nutrition Science, University of California, Davis
  • PhD, 2007 Molecular and Biochemical Nutrition, University of California, Berkeley

Committees, Societies, Councils

  • American Association of Blood Banks (AABB)
  • American Association for Clinical Chemistry (AACC)
  • American Society for Mass Spectrometry (ASMS)

Research

Selected Publications

Selected peer-reviewed publications:

  • Tiffany Thomas, Davide Stefanoni, Monika Dzieciatkowska, Aaron Issaian, Travis Nemkov, Ryan C. Hill, Richard O. Francis, Krystalyn E. Hudson, Paul W. Buehler, James C. Zimring, Eldad A. Hod, Kirk C. Hansen, Steven L. Spitalnik, and Angelo D’Alessandro Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients Journal of Proteome Research 2020 19(11), 4455-4469 DOI: 10.1021/acs.jproteome.0c00606
  • Millar J, Lassman M, Thomas T, Ramakrishnan R, Jumes P, Dunbar RL, deGoma EM, Baer AL, Karmally W, Donovan DS, Rafeek H, Wagner JA, Holleran S, Obunike J, Liu Y, Aoujil S, Standiford T, Gutstein DE, Ginsberg H, Rader DJ, Reyes-Soffer G. Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E. J Lipid Res. 2017 Jun;58(6):1214-1220.
  • Reyes-Soffer G, Pavlyha M, Ngai C, Thomas T, Holleran S, Ramakrishnan R, Karmally W, Nandakumar R, Fontanez N, Obunike J, Marcovina SM, Lichtenstein AH, Matthan NR, Matta J, Maroccia M, Becue F, Poitiers F, Swanson B, Cowan L, Sasiela W, Surks H, Ginsberg H. Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans. Circulation. 2017 Jan 24;135(4):352-362.
  • Conlon D, Thomas T, Fedotova T, Hernandez-Ono A, Di Paolo G, Chan R, Ruggles K, Gibeley S, Liu J, Ginsberg H. Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis. J Clin Invest. 2016 Oct 3;126(10):3852-3867.
  • Reyes-Soffer G, Moon B, Hernandez-Ono A, Dionizovik-Dimanovski M, Jimenez J, Obunike J, Thomas T, Ngai C, Fontanez N, Donovan D, Karmally W, Holleran S, Ramakrishnan R, Mittleman R, Ginsberg H. Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans. Sci Transl Med. 2016 Jan 27;8(323):323ra12.
  • Reyes-Soffer G, Millar J, Ngai C, Jumes P, Coromilas E, Asztalos B, Johnson-Levonas A, Wagner J, Donovan D, Karmally W, Ramakrishnan R, Holleran S, Thomas T, Dunbar R, deGoma E, Rafeek H, Baer A, Liu Y, Lassman M, Gutstein D, Rader D, Ginsberg H. Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein. Arterioscler Thromb Vasc Biol. 2016 May;36(5):994-1002.
  • Ozcan L, Xu X, Deng SX, Ghorphade DS, Thomas T, Cremers S, Hubbard B, Serrano-Wu MH, Gaestel M, Landry DW, Tabas I. Treatment of Obese Insulin-Resistant Mice with an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity. Diabetes. 2015 Oct;64(10):3396-405.
  • Jain S, Jirau-Serrano X, Zullo KM, Scotto L, Palermo CF, Sastra SA, Olive KP, Cremers S, Thomas T, Wei Y7, Zhang Y, Bhagat G, Amengual JE, Deng C, Karan C, Realubit R, Bates SE, O'Connor OA. Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma. Clin Cancer Res. 2015 May 1;21(9):2096-106.
  • Lau YK, Du X, Rayannavar V, Hopkins B, Shaw J, Bessler E, Thomas T, Pires MM, Keniry M, Parsons RE, Cremers S, Szabolcs M, Maurer MA. Metformin and erlotinib synergize to inhibit basal breast cancer. Oncotarget. 2014 Nov 15;5(21):10503-17.
  • Pan Y, Zhou H, Mahsut A, Rohm R, Berejnaia O, Price O, Chen Y, Castro-Perez J, Lassman M, McLaren D, Conway J, Jensen K, Thomas T, Reyes-Soffer G, Ginsberg H, Gutstein DE, Cleary M, Previs S, Roddy T. Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS. J Lipid Res. 2014 Apr 2;55(6):1179-1187.
  • Landolt N, Phanuphak N, Ubolyam S, Pinyakorn S, Kerr S, Ahluwalia J, Thongpaeng P, Thammajaruk N, Cremers S, Thomas T, Chaithongwongwatthana S, Lange JM, Ananworanich J. Significant decrease of ethinylestradiol with nevirapine, and of etonogestrel with efavirenz in HIV-positive women. J Acquir Immune Defic Syndr. 2014 Jun 1;66(2):e50-2.
  • Thomas T, Petrie K, Shim J, Abildskov KM, Westhoff CL, Cremers S. A UPLC-MS/MS Method for Therapeutic Drug Monitoring of Etonogestrel. Therapeutic Drug Monitoring. Ther Drug Monit. 2013 Dec;35(6):844-8.
  • Zhou H, Castro-Perez J, Lassman M, Thomas T, Li W, McLaughlin T, Xie D, Jumes P, Wagner JA, Gutstein DE, Hubbard BK, Rader DJ, Millar JS, Ginsberg H, Reyes-Soffer G, Cleary M, Previs SF, Roddy T. Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry. Rapid Communications in Mass Spectrometr. Rapid Commun Mass Spectrom. 2013 Jun 30;27(12):1294-302.
  • Thomas T, Broun EC, Abildskov KM, Kubin CJ, Horan J, Yin MT, Cremers S. High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma. Ther Drug Monit. 2012 Aug;34(4):398-405.
  • Dragoman M, Petrie K, Torgal A, Thomas T, Cremers S, Westhoff CL. Contraceptive vaginal ring effectiveness is maintained during 6 weeks of use: a prospective study of normal BMI and obese women. Contraception. 2013, In Press.
  • Westhoff CL, Torgal AH, Mayeda ER, Petrie K, Thomas T, Dragoman MV, Cremers S. Pharmacokinetics and ovarian suppression during use of a contraceptive vaginal ring in normal weight and obese women. J Obstet Gynecol. 2012; 207(1):39.e1-6.
  • Yadav VK, Oury F, Tanaka KF, Thomas T, Wang Y, Cremers S, Hen R, Krust A, Chambon P, Karsenty G. Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J Exp Med. 2011 Jan 17;208(1):41-52.
  • Thomas T, Ginsberg H. Development of apolipoprotein B antisense molecules as a therapy for hyperlipidemia. Current Atheroscler Rep 2010; 12(1):58-65.
  • Thomas T, Ginsberg H. Targeting ApoB as a therapeutic approach for the treatmentof dyslipidemia: the potential role of mipomersen. Clin Lipidol, 2010; 5(4):457-464.
  • Turner SM, Murphy EJ, Neese RA, Antelo F, Thomas T, Agarwal A, Go C, Hellerstein MK. Measurement of TG synthesis and turnover in vivo by 2H2O incorporation into the glycerol moiety and application of MIDA. Am J Physiol Endocrinol Metab 2003 Oct;285(4):E790-803.

Selected Abstracts/Seminars (National Meetings):

  • Thomas T, Genkin I, Pesce M. The Role of Specimen Handling Time on the Interpretation of Plasma Acylcarnitine Profiles for the Diagnosis of Inborn Errors of Fatty Acid Metabolism. The American Society for Mass Spectrometry Annual Meeting. 2015.
  • Thomas T, Sepulveda J, Genkin I, Pesce M. A HILIC-ESI-MS/MS method for the quantification of free and total carnitine for patient care. The American Society for Mass Spectrometry Annual Meeting. 2014.
  • Thomas T, Zott R, Cremers S. Development and validation of a HILIC Based UPLC-ESI-MS/MS method for the quantification of free carnitine in human plasma The American Society for Mass Spectrometry Annual Meeting. 2013.
  • Thomas T, Abildskov K, Westhoff C, Cremers C. Development and Validation of a UPLC-ESI-MS/MS Method for the Quantification of Etonogestrel in Human Serum. The American Society for Mass Spectrometry meeting Annual Meeting. 2012.
  • Thomas T, Zhou H, Roddy T. et al. Mechanism by Which Anacetrapib Lowers Lipoprotein (a) Concentration. Atherosclerosis, Thrombosis, and Vascular Biology Annual Meeting. 2012.
  • Sireci AN, Thomas T, Aramini B, D'Ovidio F, Pesce MA, Cremers S. An LC-MS Method for the Quantification of 4 Bile Acid Species in Broncheal Washings from Lung Transplant Patients. Clin Chem 2010; 56 (6S):A75.
  • Thomas T, Ginsberg H. Differential Effects of Antisense Knockdown of ApoB Compared with Antisense Knockdown of MTP on Hepatic Triglyceride Metabolism. Atherosclerosis, Thrombosis, and Vascular Biology meeting.2010