Tatyana S. Gindin, MD, PhD
Areas of Expertise / Conditions Treated
- Assistant Professor of Pathology & Cell Biology at CUMC
- Assistant Director of the Personalized Genomic Medicine Laboratory
After completing clinical training in Hematopathology, I joined the laboratory of Prof. Barry Honig as clinical research fellow in 2012 where I worked on development and application of biophysical and bioinformatics methods to study energetic origins of protein-protein and protein-peptide interactions. Specific applications included exploration of specificity and improvement of antibodies directed against HIV-1 gp120 envelope protein.
My current project is concentrating on using genome-wide protein-protein interaction networks developed in Prof. Honig’s laboratory to study cancer regulatory logic in the effort to understand the origins of cancer tumorigenesis and identify novel targets for therapeutics development.
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Credentials & Experience
Education & Training
- 2008 Mount Sinai School of Medicine
- Residency: 2011 NewYork-Presbyterian Hospital/Columbia University Medical Center
- Fellowship: 2006 Mount Sinai Medical Center
- Fellowship: 2013 NewYork-Presbyterian Hospital/Columbia University Medical Center
- Clinical Pathology
Honors & Awards
7/2014 – 7/2015 Shaffer-Wilk-Miller Fellowship in Clinical Pathology
7/2013 – 9/2015 NIH LRP grant
Original, Peer Reviewed Articles
Clark AJ, Gindin T, Zhang B, Wang L, Abel R, Murreta CS, Xu F, Bao A, Lu NJ, Zhou T, Kwong PD, Shapiro L, Honig B, Friesner, RA. Free Energy Perturbation Calculation of Relative Binding Free energy between Broadly Neutralizing Antibodies and the gp120 Glycoprotein of HIV-1. J. Mol. Biol. (2016), http://dx.doi.org/10.1016/j.jmb.2016.11.021
Sireci AN, Aggarwal VS, Turk AT, Gindin T, Mansukhani MM, Hsiao SJ. Clinical genomic profiling of a diverse array of oncology specimens at a large academic cancer center: Identification of targetable variants and experience with reimbursement. The Journal of Molecular Diagnostics (in press)
Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS; NISC Comparative Sequencing Program, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP Jr, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD. Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell. 2015 Jun 4;161(6):1280-92.
Alex Kentsis, Tatyana Gindin, Mihaly Mezei, Roman Osman. Calculation of the free energy and cooperativity of protein folding. PLoS ONE. 2007 May 16;2:e446.
Kentsis A, Mezei M, Gindin T, Osman R. Unfolded state of polyproline is a segmented polyproline II helix. Proteins. 2004 May 15;55(3):493-501.
Gindin T, Seibert E, Rachofsky E, Hawkins M, Ross J, Osman R. Computations of fluorescence properties of nucleotide analogues in DNA. Biophys. J. 2002: 82(1):485
Thulborn KR, Gindin TS, Davis D, Erb P. Comprehensive MR imaging protocol for stroke management: tissue sodium concentration as a measure of tissue viability in a nonhuman primate model and clinical studies. Radiology 1999 Oct;213(1):156-66.
Thulborn KR, Davis D, Adams H, Gindin T, Zhou J. Quantitative tissue sodium concentration mapping of the growth of focal cerebral tumors with sodium magnetic resonance imaging. Magn. Reson. Med. 1999. Feb 41(2):351-9.
Reviews and Editorials
Kwong PD, Chuang G, DeKosky BJ, Gindin T, Georgiev IS, Lemmin T, Schramm CA, Sheng Z, Soto C, Yang AS, Mascola JR, Shapiro L. Antibodyomics: Bioinformatics Technologies for Understanding B Cell Immunity to HIV-1. Immunological Reviews. DOI: 10.1111/imr.12480
Gindin T, Murty V, Alobeid B, Bhagat G. MLL/KMT2A translocations in diffuse large B-cell lymphomas. Hematol Oncol. 2015 Dec;33(4)239-46
Cai CX, Siringo FS, Odel JG, Lignelli-Dipple A, Lanzman B, Gindin T, Filipovich AH. Downbeat Nystagmus Secondary to Familial Hemophagocytic Lymphohistiocytosis. J. Neuroopthalmol. 2014 Mar;34(1):57-60
Mikles B, Levine J, Gindin T, Bhagat G, Satwani P. Brentuximab Vedotin (SGN-35) in a 3-year-old child with relapsed systemic anaplastic large cell lymphoma. J Pediatr Hematol Oncol. 2014 Mar;36(2):e85-7
Fang Y, Pinkney KA, Lee JC, Gindin T, Weiner MA, Alobeid B, Bhagat G. T-cell acute lymphoblastic leukaemia after liver transplantation: post-transplant lymphoproliferative disorder or coincidental de novo leukaemia? Hematol Oncol. 2013 Mar;31(1):49-53