Lorraine N. Clark, PhD

Profile Headshot

Overview

Academic Appointments

  • Associate Professor of Pathology and Cell Biology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) at CUMC

Administrative Titles

  • Assistant Medical Director, Laboratory of Personalized Genomic Medicine

Gender

  • Female

Credentials & Experience

Education & Training

  • BS, 1990 Biology (Genetics), London University (United Kingdom)
  • PhD, 1995 Molecular Biology/genetics, Manchester University

Research

Dr. Clark’s research uses genetic and genomic approaches to study the basis of neurodegenerative disease with a focus on common age-related neurodegenerative disorders including Parkinson’s disease and Essential Tremor.

Genomic technologies including next generation high throughput sequencing platforms together with computational approaches are enabling rapid advances in genetic analysis and human genetics. Her laboratory uses this technology to identify variation in both DNA sequence and gene expression levels in families, patient populations and autopsy material to determine the genetic contribution to disease pathogenesis. To identify causal and susceptibility genes they are using a variety of approaches including, exome and whole genome sequencing, SNP analysis and case-control association studies, copy number variation discovery (CNV) and analysis, genome wide association studies (GWAS), fine mapping and gene identification, resequencing and mutation analysis, transcriptomics, miRNA analysis and methylation analysis. 

Dr Clark's laboratory also uses cellular and animal models to study the disease mechanism of neurodegenerative candidate genes identified and to further our understanding of disease pathogenesis.

Research Interests

  • Genetics of neurological and neurodegenerative disease
  • Personalized genomic medicine
  • Human Genetics

Grants

IDENTIFICATION OF SUSCEPTIBILITY GENES FOR ESSENTIAL TREMOR (Federal Gov)

May 1 2015 - May 31 2020

BIOMARKERS OF ALZHEIMER S DISEASE IN ADULTS WITH DOWN SYNDROME (Federal Gov)

Sep 30 2015 - Apr 30 2020

PLANNING GRANT: COLUMBIA-YALE-BILKENT STUDY: GENETIC STUDY OF ESSENTIAL TREMOR (Federal Gov)

Sep 1 2016 - Aug 31 2018

ANALYSIS AND REPLICATION OF A GENETIC INTERACTION BETWEEN LRRK2 AND PARK16 (Private)

Oct 2 2013 - Jul 31 2016

PARKINSONS DISEASE FOUNDATION RESEARCH CENTER GRANT (Private)

Jul 1 2000 - Jun 30 2016

MECHANISMS OF DOPAMINE NEURON DEGENERATION (Federal Gov)

Aug 1 2000 - Jul 31 2015

ASYN 3 UTR MODULATION IN PARKINSON S DISEASE (Private)

Oct 1 2013 - Jun 30 2015

PARKINSONS DISEASE FOUNDATION RESEARCH CENTER GRANT (Private)

Jul 1 2000 - Jun 30 2015

AGING AND DEMENTIA IN ADULTS WITH DOWN SYNDROME (Federal Gov)

Jul 1 2010 - May 31 2015

ALZHEIMER S DISEASE RESEARCH CENTER AT COLUMBIA UNIVERSITY (Federal Gov)

Jun 1 2010 - May 31 2015

PARKINSON S DISEASE FOUNDATION RESEARCH CENTE (Private)

Jul 1 2000 - Jun 30 2014

PARKINSON S DISEASE FOUNDATION RESEARCH CENTE (Private)

Jul 1 2000 - Jun 30 2014

MOLECULAR GENETIC ANALYSIS OF LYSOSOMAL STORAGE DISORDER GEN ES IN PD (Federal Gov)

Sep 29 2008 - Aug 31 2013

PARKINSONS DISEASE FOUNDATION (PDF) RESEARCH CENTER GRANT 2012-2013 (Private)

Jul 1 2009 - Jun 30 2013

PARKINSON''S DISEASE IPS CELL LINE RESEARCH (Federal Gov)

Sep 30 2009 - Aug 31 2012

PARKINSON S DISEASE, ASHKENAZI JEWS AND LRRK2-A CONSORTIUM PROPOSAL (Private)

Jun 30 2009 - Jun 29 2012

PARKINSON S DISEASE, ASHKENAZI JEWS AND LRRK2-A CONSORTIUM PROPOSAL (Private)

Jun 30 2009 - Jun 29 2012

BETA-GLUCOCEREBROSIDASE MUTATIONS AND PARKINSON''S DISEASE IN THE ASHKENAZIM (Federal Gov)

Sep 16 2005 - Jun 30 2008