Graduate Research Faculty
| Faculty Name | Research Interests |
|---|---|
| Cory Abate–Shen | Understanding the relationship between the processes that control normal development and those that lead to cancer |
| Swarnali Acharyya | Exploring mechanisms of drug resistance and cancer metastasis, with primary focus on metastatic breast cancer and lung cancer |
| Osama Al Dalahmah | Understanding glial pathology in central nervous system (CNS) diseases. |
| Edmund Au | Mechanisms of cortical interneuron circuit assembly and interneuron dysfunction in mental illness |
| Dritan Agalliu | Signaling pathways and molecular mechanisms of CNS angiogenesis and blood-brain barrier formation in the developing CNS. Cell biological mechanisms of blood-brain barrier disruption in CNS pathologies. |
| Rando Allikmets | Stargardt macular dystrophy and other retinal diseases |
| Ottavio Arrancio | Mechanisms underlying changes of synaptic function associated with cognitive impairment |
| Richard Baer | The pathogenesis of hereditary breast cancer |
| Jonathan Barasch | Developmental and cell biology of kidney organogenesis |
| Francesca Bartolini | The role of microtubule stability and its regulation in neurodegenerative disease |
| Elizabeth Bradshaw | Understanding the role of the human innate immune system in complex neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD) |
| Julie C. Canman | Molecular mechanisms of cell division |
| Peter D. Canoll | Mechanisms of glioma growth and invasion |
| Christine Chio | Pancreatic ductal adenocarcinoma (PDAC) that represents the third leading cause of cancer death in the United States |
| Eunhee Choi | The mutual regulation between cell division and metabolism, and its impact on physiology |
| Piero Dalerba | Application of single-cell technologies for the analysis of tissue cell composition. Identification and clinical development of novel predictive biomarkers to guide therapeutic algorithm design in human colon and breast cancer |
| Riccardo Dalla-Favera | Molecular genetics of cancer; molecular pathogenesis of lymphoma and leukemia |
| Patricia Ducy | Endocrine crosstalks between the skeleton, the brain and the pancreas |
| Dieter Egli | The generation of therapeutically relevant cells for diabetes |
| Wassim Elyaman | Understanding (1) how T cells are recruited to the CNS of neurodegenerative diseases, (2) what antigens are being presented to these T cells by CNS-resident innate immune cells, microglia, (3) how microglia-T cell axis regulates the disease pathogenesis, and lastly (4) what is the influence of genetic risk variants associated with these diseases on antigen-specific immune responses. |
| Qing R. Fan | Structural biology; cell surface receptor-ligand recognition |
| Kevin Gardner | Epigenetic regulation in breast cancer |
| Jean Gautier | Understanding the molecular mechanisms responsible for the maintenance of genome stability |
| Amin Ghabrial | Regulation of tube morphogenesis using novel optogenetic tools, as well as the further elaboration of the CCM3/GckIII pathway. |
| Lloyd A. Greene | Molecular mechanisms governing neuronal differentiation and survival |
| Wei Gu | P53 in tumor suppression and aging |
| Gregg G. Gundersen | The regulation and function of the microtubule cytoskeleton |
| Rebecca A. Haeusler | Understanding the development of pro-atherogenic metabolic abnormalities in the natural history of diabetes and the metabolic syndrome |
| Gunnar Hargus | Pluripotent stem cells and their application in developmental biology and in modeling of neurodegenerative diseases with a special focus on frontotemporal dementia (FTD) |
| Ulrich Hengst | The physiological role of intra-axonal protein synthesis |
| Eldad A. Hod | Translational research focusing on the effect of modulating iron status on innate immune mechanisms |
| Krystalyn Hudson | The immune response to red blood cells (RBCs). |
| Syed Abid Hussaini | Understanding the neural correlates of cognitive dysfunction by studying regions of the brain that are most vulnerable to aging and disease |
| Minah Kim | Cancer biology and treatment; Immunotherapy; Vascular biology |
| Tae-Wan Kim | Presenilin biology and molecular mechanism of Alzheimer's disease |
| Stavroula Kousteni | Molecular studies of skeletal physiology |
| Ronald Liem | The neuronal cytoskeleton and its involvement in neurodegenerative diseases |
| W. Ian Lipkin | Immunopathogenesis and infectious diseases |
| Carol A. Mason | Molecular mechanisms of axon guidance and synaptogenesis |
| Cathy Mendelsohn | Molecular pathways controlling development of urogenital tract |
| Vilas Menon | Researching the dysregulation of cell types and cell type interactions in neurodegenerative disease, using network-based modeling of transcriptomic data |
| George Z. Mentis | Developmental organization of motor neuronal circuitry Spinal Muscular Atrophy |
| Jaewon Min | Deciphering the cellular and molecular phenomena that occur in cancer to facilitate the development of new ways to prevent, diagnose and treat cancer |
| Umrao Monani | Motor neuron disease - spinal muscular atrophy as a paradigm |
| Siddharta Mukherjee | Understanding malignant and pre-malignant blood diseases such as Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) |
| Natura Myeku | Understanding the mechanism of deficient protein quality control in tauopathy disorders that have a common feature - accumulation of pathological tau. |
| Kenneth P. Olive | Preclinical therapeutics in genetically engineered mouse models of pancreatic cancer |
| David M. Owens | The contributions of stem cells and differentiated cells to epidermal cancer |
| Teresa M. Palomero Vazquez | Elucidation of the genetic and molecular bases of T-cell leukemia and lymphoma, with special interest in the development of targeted therapies for the treatment of these aggressive hematologic tumors |
| Utpal Pajvani | The role of developmental pathways, specifically Notch signaling, in obesity-induced metabolic disease, with emphasis on the pathophysiology of Type 2 Diabetes (T2D) and Non-alcoholic Fatty Liver Disease (NAFLD) |
| Laura Pasqualucci | Elucidating the genetic basis of mature B cell malignancies, with emphasis on the two most common subtypes, diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) |
| Livio Pellizzoni | RNA Biology and Motor Neuron Pathology |
| Yueqing Peng | Epilepsy/Psychiatric Disorders; Neurobiology of Sleep; Sensory Physiology; Systems and Circutis |
| Liza A. Pon | Cytosketetal control of organelle movements and segregation during cell division |
| Serge Przedbrodski | Toxin-induced damage to neurotransmitter systems pertinent to movement disorders |
| Li Qiang | Posttranslational modifications (PTMs) of transcription factors in the pathophysiology of diabetes and obesity, and their associated comorbidities, including hepatic steatosis, cancer and cardiovascular diseases |
| Jianwen Que | Molecular and cellular mechanisms controlling proliferation and differentiation of stem/progenitor cells |
| Kapil Ramachandran | Our laboratory seeks a complete understanding of a fundamental and novel mechanism of neuronal protein homeostasis which is co-opted into a new form of neuromodulation. |
| Markus D. Siegelin | Targeting apoptosis in glioblastoma; Identification of novel drug combination therapies for glioblastoma |
| Janet Sparrow | Cell biology of retinal disorders |
| Steven Spitalnik | The biology of red blood cells |
| Andrew Sproul | Modeling the complexities of Alzheimer’s disease (AD) by using CRISPR-mediated genome-editing to introduce specific causal and risk mutations into human pluripotent stem cells (hPSCs), thus allowing more robust cross comparisons between genotypes and the creation of allelic libraries in similar genetic backgrounds. |
| Ira Tabas | Cellular and molecular processes related to arterial wall biology and atherogenesis |
| Alison Taylor | Understanding the role of aneuploidy in tumor development |
| Andrew F. Teich | Synaptic dysfunction in neurodegenerative disease, with an emphasis on Alzheimer's disease |
| Carol Troy | The study of the molecular mechanisms of neuronal death with an emphasis on the regulation of caspase activity |
| Stephen Tsang | CRISPR Genome Surgery and Metabolome Engineering in Patient-specific Stem Cells |
| Richard Vallee | Microtubule motor proteins in axonal transport, brain developmental disease, and synaptic function |
| Clarissa Waites | Roles of protein ubiquitination in synaptic function and neurodegeneration |
| Harris Wang | Understanding the key principles that drive the formation, maintenance, and evolution of genomes within and across microbial populations |
| Stuart Weisberg | How anatomy and organ microenvironment specify immune cell phenotype and function in health and disease. |
| Hynek Wichterle | The use of stem cells to study the development and function of the nervous system |
| Robert Winchester | Autoimmunity and autoimmune disease |
| Howard J. Worman | The studies of the inner nuclear membrane and its proteins |
| Ai Yamamoto | Protein trafficking in Huntington’s disease and other neurological disorders |
| Darrell Yamashiro | The role of angiogenesis in promoting the growth and metastasis of pediatric solid tumors |
| Hee Won Yang | Understanding the signaling processes that underlie the decision to proliferate |
| Andrew Yates | The evolution of immune repertoires throughout an individual's lifespan, and their recovery in HIV-infected individuals following antiretroviral therapy. |
| Lori Zeltser | Developing Circuits Regulating Food Intake and Body Weight |
| Shan Zha | The molecular mechanisms of DNA damage response and their roles in lymphocyte gene-rearrangement |
| Xin Zhang | Investigating the mechanism of cell signaling during eye development |
| Zhiguo Zhang | Epigenetic inheritance and cancer epigenetics |